The bus between Des Moines and St. Louis takes 12h 20m. The bus runs, on average, 6 times per week from Des Moines to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 6 times a week between Des Moines and St. Louis. The earliest departure is at 11:45 PM at night, and the last departure from Des Moines is at 11:45 PM which arrives into St. Louis at 12:05 PM. All services require a transfer, and take on average 12h 20m. The schedules shown below are for the next available departures.
Want to know about travelling from Des Moines to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Des Moines to St. Louis. However, there are services departing from Des Moines station and arriving at St. Louis station via Kansas City. The journey, including transfers, takes approximately 12h 20m.
Des Moines to St. Louis bus services, operated by Jefferson Lines, depart from Des Moines station.
Des Moines to St. Louis bus services, operated by Jefferson Lines, arrive at St Louis Bus Station.
The distance between Des Moines and St. Louis is 439.8 km. The road distance is 715 km.
You can take a bus from Des Moines to St Louis Bus Station via Kansas City Bus Station in around 8h 30m.
