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How to get fromIndianapolis to St. Louisby bus (Greyhound), train (Amtrak), car, plane or train

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There are 5 ways to get from Indianapolis to St. Louis by bus (Greyhound), train (Amtrak), car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Indianapolis Union Station to St Louis Bus StationbusGreyhound US0421
    3h 55m
    $35–120

  2. Train (Amtrak)

    1. Take the train from Indianapolis to Chicago Union StationtrainCardinal
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    10h 46m
    $76–578

  3. Drive 241.8 mi

    1. Drive from Indianapolis to St. Louiscar241.8 mi
    4h
    $45–64

  4. Fly from Indianapolis

    1. Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)planeIND - STL
    5h 44m
    $295–655

  5. Train to Purdue University Airport, fly

    1. Take the train from Indianapolis to Lafayette Amtrak Stationtrain
    2. Fly from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL)planeLAF - STL
    8h 17m
    $110–555

Indianapolis to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration3h 55mAverage Duration
Ticket$35Cheapest Price
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Questions & Answers

What companies run services between Indianapolis, IN, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Indianapolis Union Station to St Louis Bus Station 3 times a day. Tickets cost $35–120 and the journey takes 3h 55m. Alternatively, you can take a train from Indianapolis to St. Louis via Chicago Union Station in around 10h 46m.

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