There are 5 ways to get from Indianapolis to St. Louis by bus (Greyhound), train (Amtrak), car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Greyhound)
best- Take the bus from Indianapolis Union Station to St Louis Bus Stationbus Greyhound US0421
3h 55m$30–75Train (Amtrak)
- Take the train from Indianapolis to Chicago Union Stationtrain Cardinal
- Take the train from Chicago Union Station to St. Louistrain Lincoln Service / ...
10h 46m$71–273Drive 241.8 mi
- Drive from Indianapolis to St. Louiscar 241.8 mi
4h 2m$45–64Fly from Indianapolis
- Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)plane IND - STL
6h 4m$295–555Train to Purdue University Airport, fly
- Take the train from Indianapolis to Lafayette Amtrak Stationtrain
- Fly from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL)plane LAF - STL
7h 55m$105–605
Indianapolis to St. Louis by bus (Greyhound)
Questions & Answers
The cheapest way to get from Indianapolis to St. Louis is to bus which costs $30 - $75 and takes 3h 55m.
The fastest way to get from Indianapolis to St. Louis is to bus which takes 3h 55m and costs $30 - $75.
Yes, there is a direct bus departing from Indianapolis Union Station station and arriving at St Louis Bus Station station. Services depart three times a day, and operate every day. The journey takes approximately 3h 55m.
No, there is no direct train from Indianapolis to St. Louis. However, there are services departing from Indianapolis and arriving at St. Louis via Chicago Union Station. The journey, including transfers, takes approximately 10h 46m.
The distance between Indianapolis and St. Louis is 243 miles. The road distance is 243.2 miles.
The best way to get from Indianapolis to St. Louis without a car is to bus which takes 3h 55m and costs $30 - $75.
The bus from Indianapolis, Illinois St (Greyhound Bus Station) to St Louis Bus Station takes 3h 55m including transfers and departs three times a day.
Indianapolis to St. Louis bus services, operated by Greyhound USA, depart from Indianapolis Union Station.
Indianapolis to St. Louis train services, operated by Amtrak, depart from Indianapolis station.
The best way to get from Indianapolis to St. Louis is to bus which takes 3h 55m and costs $30 - $75. Alternatively, you can train, which costs $70 - $280 and takes 10h 46m, you could also fly, which costs $290 - $600 and takes 6h 4m.
What companies run services between Indianapolis, IN, USA and St. Louis, MO, USA?
Greyhound USA operates a bus from Indianapolis Union Station to St Louis Bus Station 3 times a day. Tickets cost $30–75 and the journey takes 3h 55m. Alternatively, you can take a train from Indianapolis to St. Louis via Chicago Union Station in around 10h 46m.
- Website
- united.com
Flights from Indianapolis to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $95–650
Flights from Purdue University Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 53m
- When
- Every day
- Estimated price
- $80–550
- Website
- delta.com
Flights from Indianapolis to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $120–700
Flights from Indianapolis to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $150–800
Flights from Indianapolis to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 29m
- When
- Every day
- Estimated price
- $140–800
- Website
- southwest.com
Flights from Indianapolis to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $95–600
Flights from Indianapolis to Lambert–St. Louis International Airport via Kansas City
- Ave. Duration
- 3h 35m
- When
- Monday
- Estimated price
- $120–700
Flights from Indianapolis to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $140–800
- Website
- aa.com
Flights from Indianapolis to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 5m
- When
- Every day
- Estimated price
- $95–650
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Indianapolis to Chicago Union Station
- Ave. Duration
- 5h
- Frequency
- 3 times a week
- Estimated price
- $35–75
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $35–200
- Website
- https://www.amtrak.com/home.html
Train from Indianapolis to Lafayette Amtrak Station
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a week
- Estimated price
- $21–55
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Indianapolis Union Station to St Louis Bus Station
- Ave. Duration
- 3h 55m
- Frequency
- 3 times a day
- Estimated price
- $30–75
- Website
- https://www.greyhound.com/
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More Questions & Answers
Indianapolis to St. Louis bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
St. Louis is 1h behind Indianapolis. It is currently 12:13 PM in Indianapolis and 11:13 AM in St. Louis.
Indianapolis to St. Louis train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Indianapolis to St. Louis is 243 miles. It takes approximately 4h 2m to drive from Indianapolis to St. Louis.
Book your Indianapolis to St. Louis train tickets online with Omio.
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