The average bus between Des Moines and Boston takes 40h 21m and the fastest bus takes 34h 55m. There is at least one bus per day from Des Moines to Boston. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Des Moines and Boston. The earliest departure is at 9:20 AM in the morning, and the last departure from Des Moines is at 9:45 AM which arrives into Boston at 11:15 AM. All services require a transfer at Chicago Bus Station and take an average of 40h 21m. The schedules shown below are for the next available departures.
Arrives next day


35h 55m • 2 changes
Arrives +2 days


2d 1h • 2 changes
Arrives next day


35h 55m • 2 changes
Arrives +2 days


2d 1h • 2 changes
Arrives next day


35h 55m • 2 changes
Arrives +2 days


2d 1h • 2 changes
Want to know about travelling from Des Moines to Boston? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Des Moines to Boston. However, there are services departing from Des Moines station and arriving at Boston station via Chicago Bus Station station. The journey, including transfers, takes approximately 40h 21m.
Des Moines to Boston bus services, operated by Greyhound USA, depart from Des Moines station.
Des Moines to Boston bus services, operated by Greyhound USA, arrive at Boston station.
Book your Des Moines to Boston bus tickets online with Greyhound USA and Flixbus USA.
The distance between Des Moines and Boston is 1,860.4 km. The road distance is 2,311 km.
You can take a bus from Des Moines to Boston via Chicago Bus Station and New York Midtown in around 30h 23m.