Rome2Rio

Des Moines to Boston buses

Find Transport to Boston

View schedule

Trip Overview

The average bus between Des Moines and Boston takes 40h 53m and the fastest bus takes 35h 45m. There is at least one bus per day from Des Moines to Boston. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

40h 53m
Duration
1,535 mi
Distance
$302
Average price
Once daily
Frequency

Des Moines to Boston bus times

Buses run once daily between Des Moines and Boston. The earliest departure is at 9:20 AM in the morning, and the last departure from Des Moines is at 9:45 AM which arrives into Boston at 12:55 PM. All services require a transfer at Chicago Bus Station and take an average of 40h 53m. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA37h • 2 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USA2d 2h • 2 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA35h 45m • 2 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA35h 45m • 2 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USA2d • 2 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA35h 45m • 2 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USA2d • 2 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA35h 45m • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to Boston? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Boston.ExpandLaunch map view
  • Distance: 1,534.9 mi
  • Duration: 40h 53m

What companies run services between Des Moines, IA, USA and Boston, MA, USA?

You can take a bus from Des Moines to Boston via Chicago Bus Station and New York Midtown in around 33h 29m.

Operators