The average bus between Des Moines and Manhattan takes 36h 17m and the fastest bus takes 30h 5m. The bus service runs several times per day from Des Moines to Manhattan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Des Moines and Manhattan. The earliest departure is at 9:20 AM in the morning, and the last departure from Des Moines is at 9:45 AM which arrives into Manhattan at 6:30 AM. All services require a transfer, and take on average 36h 17m. The schedules shown below are for the next available departures.
Arrives next day

31h 5m • 1 change
Arrives +2 days

44h 45m • 1 change
Arrives next day

31h 5m • 1 change
Arrives +2 days

44h 45m • 1 change
Arrives next day

31h 5m • 1 change
Arrives +2 days

44h 45m • 1 change
Want to know about travelling from Des Moines to Manhattan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Des Moines to Manhattan. However, there are services departing from Des Moines station and arriving at Manhattan station via Chicago Bus Station station. The journey, including transfers, takes approximately 36h 17m.
Des Moines to Manhattan bus services, operated by Greyhound USA, depart from Des Moines station.
Des Moines to Manhattan bus services, operated by Greyhound USA, arrive at New York Midtown station.
Book your Des Moines to Manhattan bus tickets online with Greyhound USA and Flixbus USA.
The distance between Des Moines and Manhattan is 1,642.6 km. The road distance is 2,131 km.
You can take a bus from Des Moines to New York Midtown via Chicago Bus Station in around 28h 15m.