The average bus between Comiso and Siena takes 22h 30m and the fastest bus takes 16h 25m. The bus service runs several times per day from Comiso to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Comiso and Siena. The earliest departure is at 3:20 PM in the afternoon, and the last departure from Comiso is at 9:50 PM which arrives into Siena at 12:40 AM. All services require a transfer at Ragusa Bus Terminal and take an average of 22h 30m. The schedules shown below are for the next available departures.
Arrives next day


16h 25m • 2 changes
Arrives +2 days


26h 50m • 2 changes
Arrives next day


16h 25m • 2 changes
Arrives +2 days


30h 20m • 2 changes
Arrives next day


16h 25m • 2 changes
Arrives +2 days


33h 55m • 2 changes
Arrives next day


16h 25m • 2 changes
Arrives +2 days


26h 50m • 2 changes
Want to know about travelling from Comiso to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Comiso to Siena. However, there are services departing from Comiso station and arriving at Siena station via Aeroporto Vincenzo Bellini/Fontanarossa. The journey, including transfers, takes approximately 22h 30m.
Comiso to Siena bus services, operated by Azienda Siciliana Trasporti, depart from Ragusa Bus Terminal station.
Comiso to Siena bus services, operated by Azienda Siciliana Trasporti, arrive at Siena station.
Book your Comiso to Siena bus tickets online with Azienda Siciliana Trasporti, Interbus and FlixBus.
The distance between Comiso and Siena is 760.9 km. The road distance is 1,113 km.
You can take a bus from Comiso to Siena via Ragusa Bus Terminal, Aeroporto Vincenzo Bellini/Fontanarossa, and Catania Airport in around 18h.