There are 10 ways to get from Comiso to Siena by plane, train, bus, train (Trenitalia), night train, car, or car ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Vincenzo Magliocco Airport to Pisa International Airport, train
best- Fly from Vincenzo Magliocco Airport (CIY) to Pisa International Airport (PSA)plane CIY - PSA
- Take the train from Pisa Centrale to Empolitrain
- Take the train from Empoli to Sienatrain
4h 4m€110–355Bus to Catania–Fontanarossa Airport, fly to Florence Peretola Airport, train
cheapest- Take the bus from Gela Bus Station to Catania Fontanarossa Airport Bus Stopbus
- Fly from Catania–Fontanarossa Airport (CTA) to Florence Peretola Airport (FLR)plane CTA - FLR
- Take the train from Firenze S.M.N. to Sienatrain
7h 57m€59–207Bus via Catania Airport (CTA)
- Take the bus from Ragusa Bus Terminal to Aeroporto Vincenzo Bellini/Fontanarossabus Ragusa
- Take the bus from Catania Airport to Sienabus N597 / ...
18h€66–152Train (Trenitalia)
- Take the train from Comiso to Siracusatrain Re
- Take the train from Siracusa to Roma Terminitrain Ic
- Take the train from Roma Termini to Firenze S.M.N.train Fr
- Take the train from Firenze S.M.N. to Sienatrain Re
18h 38m€142–312Train, night train
- Take the train from Comiso to Siracusatrain Re
- Take the nighttrain from Siracusa to Firenze Campo Martenighttrain Ini
- Take the train from Firenze S.M.N. to Sienatrain Re
21h 56m€130–258Fly Vincenzo Magliocco Airport to Florence Peretola Airport, train
- Fly from Vincenzo Magliocco Airport (CIY) to Florence Peretola Airport (FLR)plane CIY - FLR
- Take the train from Firenze S.M.N. to Sienatrain
5h 56m€116–406Fly Vincenzo Magliocco Airport to Bologna Guglielmo Marconi Airport, train
- Fly from Vincenzo Magliocco Airport (CIY) to Bologna Guglielmo Marconi Airport (BLQ)plane CIY - BLQ
- Take the train from Bologna Centrale to Firenze S.M.N.train
- Take the train from Firenze S.M.N. to Sienatrain
4h 40m€103–361Fly Vincenzo Magliocco Airport to Fiumicino International Airport, train
- Fly from Vincenzo Magliocco Airport (CIY) to Fiumicino International Airport (FCO)plane CIY - FCO
- Take the train from Roma Termini to Firenze S.M.N.train
- Take the train from Firenze S.M.N. to Sienatrain
5h 45m€96–336Bus
- Take the bus from Gela Bus Station to Florence Villa Constanza Bus Stationbus
- Take the bus from Stazione Leopolda to Siena-Via Tozzibus 131R / ...
21h 17mDrive, car ferry
- Drive from Comiso to Tresmestiericar
- Take the carferry from Tresmestieri to Villa S. Giovannicarferry
- Drive from Villa S. Giovanni to Sienacar
11h 10m€177–286
Comiso to Siena by bus
Questions & Answers
The cheapest way to get from Comiso to Siena is to bus via Catania Airport (CTA) which costs €65 - €160 and takes 18h.
The fastest way to get from Comiso to Siena is to fly and train which takes 4h 4m and costs €110 - €360.
No, there is no direct bus from Comiso to Siena. However, there are services departing from Comiso and arriving at Siena via Ragusa Bus Terminal and Catania Airport. The journey, including transfers, takes approximately 18h.
No, there is no direct train from Comiso to Siena. However, there are services departing from Comiso and arriving at Siena via Siracusa, Roma Termini and Firenze S.M.N.. The journey, including transfers, takes approximately 18h 38m.
The distance between Comiso and Siena is 944 km.
The best way to get from Comiso to Siena without a car is to bus via Catania Airport (CTA) which takes 18h and costs €65 - €160.
It takes approximately 4h 4m to get from Comiso to Siena, including transfers.
Comiso to Siena bus services, operated by Interbus, depart from Ragusa Bus Terminal station.
Comiso to Siena train services, operated by Trenitalia, depart from Comiso station.
The best way to get from Comiso to Siena is to bus via Catania Airport (CTA) which takes 18h and costs €65 - €160. Alternatively, you can train, which costs €140 - €320 and takes 18h 38m.
What companies run services between Comiso, Italy and Siena, Italy?
You can take a bus from Comiso to Siena via Ragusa Bus Terminal, Aeroporto Vincenzo Bellini/Fontanarossa, and Catania Airport in around 18h. Alternatively, you can take a train from Comiso to Siena via Siracusa, Roma Termini, and Firenze S.M.N. in around 18h 38m.
- Website
- flexflight.dk
Flights from Vincenzo Magliocco Airport to Pisa International Airport
- Ave. Duration
- 1h 40m
- When
- Thursday and Sunday
- Estimated price
- €60–800
Flights from Vincenzo Magliocco Airport to Florence Peretola Airport via Fiumicino International Airport, Elba Island
- Ave. Duration
- 5h 50m
- When
- Thursday
- Estimated price
- €95–950
Flights from Vincenzo Magliocco Airport to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 40m
- When
- Monday and Friday
- Estimated price
- €110–800
Flights from Vincenzo Magliocco Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €40–600
- Website
- aeroitalia.com
Flights from Vincenzo Magliocco Airport to Pisa International Airport
- Ave. Duration
- 1h 40m
- When
- Thursday and Sunday
- Estimated price
- €60–800
Flights from Vincenzo Magliocco Airport to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 40m
- When
- Monday and Friday
- Estimated price
- €110–800
Flights from Vincenzo Magliocco Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €40–600
- Website
- ita-airways.com
Flights from Vincenzo Magliocco Airport to Florence Peretola Airport via Fiumicino International Airport
- Ave. Duration
- 3h 45m
- When
- Every day
- Estimated price
- €90–950
Flights from Catania–Fontanarossa Airport to Florence Peretola Airport via Fiumicino International Airport
- Ave. Duration
- 3h 41m
- When
- Every day
- Estimated price
- €80–170
- Website
- volotea.com
Flights from Catania–Fontanarossa Airport to Florence Peretola Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €27–140
Flights from Catania–Fontanarossa Airport to Florence Peretola Airport via Fiumicino International Airport
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- €80–170
- Website
- flyulendo.com
Flights from Vincenzo Magliocco Airport to Pisa International Airport via Tirana
- Ave. Duration
- 4h 15m
- When
- Tuesday and Saturday
- Estimated price
- €100–220
- Website
- vueling.com
Flights from Catania–Fontanarossa Airport to Florence Peretola Airport
- Ave. Duration
- 1h 40m
- When
- Monday, Friday, and Sunday
- Estimated price
- €50–190
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Pisa Centrale to Empoli
- Ave. Duration
- 45 min
- Frequency
- Every 15 minutes
- Estimated price
- €5–10
- Website
- Trenitalia
Train from Empoli to Siena
- Ave. Duration
- 1h
- Frequency
- Every 30 minutes
- Estimated price
- €7–13
- Website
- Trenitalia
Train from Comiso to Siracusa
- Ave. Duration
- 2h 45m
- Frequency
- 5 times a day
- Estimated price
- €17–29
- Website
- Trenitalia
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 3h 35m
- Frequency
- Every 3 hours
- Estimated price
- €30–55
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Comiso to Siracusa
- Ave. Duration
- 2h 45m
- Frequency
- 5 times a day
- Estimated price
- €17–29
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 35m
- Frequency
- 4 times a day
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 3h 35m
- Frequency
- Every 3 hours
- Estimated price
- €30–55
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Siracusa to Roma Termini
- Ave. Duration
- 11h 9m
- Frequency
- 4 times a day
- Estimated price
- €85–190
- Website
- Trenitalia Intercity
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 3h 45m
- Frequency
- Twice daily
- Estimated price
- €28–60
- Website
- Trenitalia Intercity
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 16m
- Frequency
- 3 times a day
- Estimated price
- €9–21
- Website
- Trenitalia Intercity
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 3h 45m
- Frequency
- Twice daily
- Estimated price
- €28–60
- Website
- Trenitalia Intercity
- Phone
- +39 06 68475475
- Website
- Trenitalia Frecce
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 1h 42m
- Frequency
- Every 15 minutes
- Estimated price
- €35–75
- Schedules at
- Trenitalia Frecce
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 37 min
- Frequency
- Every 15 minutes
- Estimated price
- €13–27
- Schedules at
- Trenitalia Frecce
Train from Roma Termini to Firenze S.M.N.
- Ave. Duration
- 1h 42m
- Frequency
- Every 15 minutes
- Estimated price
- €35–75
- Schedules at
- Trenitalia Frecce
- Phone
- 06 3000
- Website
- Trenitalia ICN
Night train from Siracusa to Firenze Campo Marte
- Ave. Duration
- 16h 1m
- Frequency
- 4 times a week
- Estimated price
- €100–210
- Website
- Trenitalia ICN
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 46 min
- Frequency
- 5 times a day
- Estimated price
- €11–23
- Website
- Italo Treno
- Phone
- +39 0935 22 460
- Website
- interbus.it
Bus from Ragusa Bus Terminal to Aeroporto Vincenzo Bellini/Fontanarossa
- Ave. Duration
- 1h 45m
- Frequency
- Every 3 hours
- Estimated price
- €6–12
- Schedules at
- interbus.it
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Catania Airport to Siena
- Ave. Duration
- 13h 45m
- Frequency
- Twice daily
- Estimated price
- €80–140
- Website
- Flixbus
- Phone
- +39 06 88 93 82 32
- Website
- Itabus S.p.A.
Bus from Catania Airport to Siena
- Ave. Duration
- 14h 55m
- Frequency
- Once daily
- Estimated price
- €60–130
- Website
- Itabus S.p.A.
- Phone
- +39 06 164160
- info@etnatrasporti.it
- Website
- etnatrasporti.it
Bus from Gela Bus Station to Catania Fontanarossa Airport Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- Every 3 hours
- Estimated price
- €6–8
- Schedules at
- etnatrasporti.it
- Phone
- +39 0362 185 0590
- info@onebus.it
- Website
- Onebus
Bus from Gela Bus Station to Florence Villa Constanza Bus Station
- Ave. Duration
- 17h 48m
- Frequency
- Twice a week
- Website
- Onebus
- Phone
- +39 800 142 424
- numeroverdetpl@regione.toscana.it
- Website
- Autolinee Toscane
Bus from Stazione Leopolda to Siena-Via Tozzi
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €4–6
- Website
- Autolinee Toscane
- Schedules at
- Autolinee Toscane
- Phone
- 090774409
- info@bluferries.it
- Website
- bluferries.it
Car ferry from Tresmestieri to Villa S. Giovanni
- Ave. Duration
- 25 min
- Frequency
- Hourly
- Estimated price
- €19–35
- Schedules at
- bluferries.it
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
5 incredible day trips from Florence by train
Read the travel guide
More Questions & Answers
Comiso to Siena bus services, operated by Interbus, arrive at Aeroporto Vincenzo Bellini/Fontanarossa station.
Comiso to Siena train services, operated by Trenitalia, arrive at Siracusa station.
Book your Comiso to Siena train tickets online with Omio.
Book your Comiso to Siena bus tickets online with Omio.
There are 2524+ hotels available in Siena.









































