The average bus between Comiso and Messina takes 6h 36m and the fastest bus takes 4h 25m. The bus service runs several times per day from Comiso to Messina. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Comiso and Messina. The earliest departure is at 7:00 AM in the morning, and the last departure from Comiso is at 9:50 PM which arrives into Messina at 1:20 PM. All services require a transfer at Ragusa Bus Terminal and take an average of 6h 36m. The schedules shown below are for the next available departures.


6h 20m • 2 changes


5h • 2 changes


4h 45m • 2 changes


4h 25m • 2 changes


5h • 2 changes


4h 45m • 2 changes


4h 25m • 2 changes
Arrives next day


12h 10m • 2 changes


5h • 2 changes


4h 45m • 2 changes


4h 25m • 2 changes
Arrives next day


12h 10m • 2 changes
Want to know about travelling from Comiso to Messina? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Comiso to Messina. However, there are services departing from Comiso station and arriving at Messina station via Catania Via Archimede. The journey, including transfers, takes approximately 6h 36m.
Comiso to Messina bus services, operated by Azienda Siciliana Trasporti, depart from Ragusa Bus Terminal station.
Comiso to Messina bus services, operated by Azienda Siciliana Trasporti, arrive at Messina Piazza della Repubblica station.
Book your Comiso to Messina bus tickets online with Azienda Siciliana Trasporti, Interbus and FlixBus.
The distance between Comiso and Messina is 161.6 km. The road distance is 209 km.
You can take a bus from Comiso to Messina Piazza della Repubblica via Ragusa Bus Terminal and Catania Central Bus Station in around 5h 55m.