The average bus between Chicago and St. Louis takes 6h 16m and the fastest bus takes 5h 55m. The bus service runs several times per day from Chicago to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Chicago and St. Louis. The earliest departure is at 12:15 AM at night, and the last departure from Chicago is at 4:30 PM which arrives into St. Louis at 11:10 PM. All services run direct with no transfers required, and take on average 6h 16m. The schedules shown below are for the next available departures.
Want to know about travelling from Chicago to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
Yes, there is a direct bus departing from Chicago station and arriving at St. Louis station. Services depart 3 times a day, and operate Once daily. The journey takes approximately 6h 16m.
Chicago to St. Louis bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to St. Louis bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
Book your Chicago to St. Louis bus tickets online with Flixbus USA.
The distance between Chicago and St. Louis is 421.9 km. The road distance is 512 km.
Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day. Tickets cost $35–70 and the journey takes 6h 10m.
