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Presque Isle to St. Louis buses

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Trip Overview

The bus between Presque Isle and St. Louis takes 40h 25m. The bus runs, on average, 4 times per week from Presque Isle to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

40h 25m
Duration
1,668 mi
Distance
$349
Average price
4 times a week
Frequency

Presque Isle to St. Louis bus times

Buses run 4 times a week between Presque Isle and St. Louis. The service departs Presque Isle at 7:25 AM in the morning, which arrives into St. Louis at 22:50:00. All services require a transfer at Bangor, ME and take an average of 40h 25m. The schedules shown below are for the next available departures.

Departing Friday, November 13, 2026

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    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAGreyhound USA40h 25m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAGreyhound USA40h 25m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAGreyhound USA40h 25m • 3 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAGreyhound USA40h 25m • 3 changes

Frequently asked questions

Want to know about travelling from Presque Isle to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Presque Isle to St. Louis.ExpandLaunch map view
  • Distance: 1,667.9 mi
  • Duration: 40h 25m

What companies run services between Presque Isle, ME, USA and St. Louis, MO, USA?

You can take a bus from Presque Isle, Maine to St Louis Bus Station via Bangor, ME, Bangor Transportation Center, Boston, MA - South Station, Boston, and Newark Penn Station in around 37h 50m.

Operators