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There are 6 ways to get from Chicago to St. Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Chicago Midway  •  3 h 16 min

  1. Fly from Chicago Midway (MDW) to St. Louis (STL) MDW - STL

$125 - $307

Cheapest option

Bus  •  6 h

  1. Take the bus from Chicago, IL to St. Louis via St Louis / ...

$29 - $80

4 alternative options

Fly from Chicago O'Hare  •  3 h 28 min

  1. Fly from Chicago O'Hare (ORD) to St. Louis (STL) ORD - STL

$90 - $248

Bus to Milwaukee, fly  •  5 h 27 min

  1. Take the bus from Chicago, IL - O'Hare International Airport to Milwaukee, WI - Airport
  2. Fly from Milwaukee (MKE) to St. Louis (STL) MKE - STL

$155 - $313

Train  •  5 h 30 min

  1. Take the train from Chicago Union Station to St. Louis Gateway Station Lincoln Service / ...

$50 - $130

Drive  •  4 h 53 min

  1. Drive from Chicago to St. Louis 297.4 miles

$29 - $45

Questions & Answers

The cheapest way to get from Chicago to St. Louis is to drive which costs $29 - $45 and takes 4 h 53 min.

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The quickest way to get from Chicago to St. Louis is to fly which costs $120 - $310 and takes 3 h 16 min.

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Yes, there is a direct bus departing from Chicago, IL and arriving at St. Louis. Services depart three times a day, and operate every day. The journey takes approximately 6 h.

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Yes, there is a direct train departing from Chicago Union Station station and arriving at St. Louis Gateway Station station. Services depart every four hours, and operate every day. The journey takes approximately 5 h 30 min.

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The distance between Chicago and St. Louis is 264 miles. The road distance is 297.4 miles.

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The best way to get from Chicago to St. Louis without a car is to train which takes 5 h 30 min and costs $50 - $130.

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It takes approximately 3 h 16 min to get from Chicago to St. Louis, including transfers.

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Chicago to St. Louis bus services, operated by Megabus, depart from Chicago, IL station.

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Chicago to St. Louis train services, operated by Amtrak, arrive at Chicago Union Station.

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The best way to get from Chicago to St. Louis is to fly which takes 3 h 16 min and costs $120 - $310. Alternatively, you can train, which costs $50 - $130 and takes 5 h 30 min, you could also bus, which costs $29 - $80 and takes 6 h.

Mode details

Map of how to get from Chicago to St. Louis.
Launch map view
  • Distance: 263.7 miles
  • Duration: 3 h 16 min

What companies run services between Chicago, IL, USA and St. Louis, MO, USA?

Southwest Airlines flies from Chicago to St. Louis every 4 hours. Alternatively, Amtrak operates a train from Chicago to St. Louis every 4 hours. Tickets cost $50 - $130 and the journey takes 5 h 30 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to St. Louis
Ave. Duration
1 h 7 min
When
Every day
Estimated price
$160 - $550
Flights from Milwaukee to St. Louis
Ave. Duration
1 h 15 min
When
Every day
Estimated price
$310 - $600
United Airlines
Website
united.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1 h 20 min
When
Every day
Estimated price
$120 - $650
Flights from Milwaukee to St. Louis via Chicago O'Hare
Ave. Duration
3 h 12 min
When
Every day
Estimated price
$240 - $750
American Airlines
Website
aa.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1 h 10 min
When
Every day
Estimated price
$120 - $550
Flights from Milwaukee to St. Louis via Chicago O'Hare
Ave. Duration
3 h 15 min
When
Every day
Estimated price
$230 - $550
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5 h 30 min
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Coach USA
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to St Louis, Mo
Ave. Duration
5 h 10 min
Frequency
Once daily
Estimated price
$30 - $80
Website
greyhound.com
Economy
$30 - $55
Flexible
$60 - $80

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Chicago Midway Airport to St. Louis Airport is the direct flight which takes 1 h 5 min.

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Chicago to St. Louis bus services, operated by Megabus, arrive at St. Louis station.

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Chicago to St. Louis train services, operated by Amtrak, arrive at St. Louis Gateway Station.

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Yes, the driving distance between Chicago to St. Louis is 297 miles. It takes approximately 4 h 53 min to drive from Chicago to St. Louis.

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Southwest Airlines offers flights from Chicago Midway Airport to St. Louis Airport.

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Book your Chicago to St. Louis train tickets online with Rome2rio.

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Book your Chicago to St. Louis bus tickets online with Greyhound.

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There are 193+ hotels available in St. Louis. Prices start at $69 USD per night.

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The best way to get from Chicago to Chicago Midway Airport is to subway which takes 23 min and costs $2 - $4.

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