There are 6 ways to get from Chicago to St. Louis by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Chicago Midway  •  3h 12m

  1. Fly from Chicago Midway (MDW) to St. Louis (STL) MDW - STL

$146 - $278

Cheapest option

Bus  •  6h 40m

  1. Take the bus from Chicago, Il to Greyhound Bus Station St. Louis 1163 / ...

$25 - $55

4 alternative options

Fly from Chicago O'Hare  •  3h 31m

  1. Fly from Chicago O'Hare (ORD) to St. Louis (STL) ORD - STL

$80 - $278

Train to Milwaukee, fly  •  5h 7m

  1. Take the train from Chicago Union Station to Milwaukee Intermodal Station
  2. Fly from Milwaukee (MKE) to St. Louis (STL) MKE - STL

$143 - $514

Train  •  5h 30m

  1. Take the train from Chicago Union Station to St. Louis Gateway Station Lincoln Service / ...

$40 - $60

Drive  •  4h 53m

  1. Drive from Chicago to St. Louis 297.4 miles

$29 - $45

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Questions & Answers

The cheapest way to get from Chicago to St. Louis is to drive which costs $29 - $45 and takes 4h 53m.

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The quickest way to get from Chicago to St. Louis is to fly which costs $140 - $280 and takes 3h 12m.

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Yes, there is a direct bus departing from Chicago, Il and arriving at Greyhound Bus Station St. Louis station. Services depart every three hours, and operate every day. The journey takes approximately 6h 40m.

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Yes, there is a direct train departing from Chicago Union Station station and arriving at St. Louis Gateway Station station. Services depart five times a day, and operate every day. The journey takes approximately 5h 30m.

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The distance between Chicago and St. Louis is 264 miles. The road distance is 297.4 miles.

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The best way to get from Chicago to St. Louis without a car is to train which takes 5h 30m and costs $40 - $60.

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It takes approximately 3h 12m to get from Chicago to St. Louis, including transfers.

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Chicago to St. Louis bus services, operated by Greyhound USA, depart from Chicago, Il station.

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Chicago to St. Louis train services, operated by Amtrak, depart from Chicago Union Station.

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The best way to get from Chicago to St. Louis is to fly which takes 3h 12m and costs $140 - $280. Alternatively, you can train, which costs $40 - $60 and takes 5h 30m, you could also bus, which costs $25 - $55 and takes 6h 40m.

Mode details

Map of how to get from Chicago to St. Louis.
Launch map view
  • Distance: 263.7 miles
  • Duration: 3h 12m

What companies run services between Chicago, IL, USA and St. Louis, MO, USA?

Southwest Airlines flies from Chicago to St. Louis every 4 hours. Alternatively, Amtrak operates a train from Chicago Union Station to St. Louis Gateway Station 5 times a day. Tickets cost $40 - $60 and the journey takes 5h 30m.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to St. Louis
Ave. Duration
1h 8m
When
Every day
Estimated price
$140 - $600
Flights from Milwaukee to St. Louis
Ave. Duration
1h 17m
When
Every day
Estimated price
$110 - $470
Flights from Milwaukee to St. Louis via Kansas City
Ave. Duration
3h 30m
When
Monday to Friday
Estimated price
$120 - $550
United Airlines
Website
united.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1h 23m
When
Every day
Estimated price
$130 - $280
Flights from Milwaukee to St. Louis via Chicago O'Hare
Ave. Duration
3h 24m
When
Every day
Estimated price
$160 - $650
American Airlines
Website
aa.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1h 8m
When
Every day
Estimated price
$100 - $310
Flights from Chicago O'Hare to St. Louis via Quincy
Ave. Duration
2h 55m
When
Every day
Estimated price
$90 - $290
Flights from Milwaukee to St. Louis via Chicago O'Hare
Ave. Duration
3h 20m
When
Every day
Estimated price
$100 - $550
Cape Air
Website
capeair.com
Flights from Chicago O'Hare to St. Louis via Quincy
Ave. Duration
2h 55m
When
Every day
Estimated price
$90 - $290
GoJet Airlines
Website
gojetairlines.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1h 21m
When
Every day
Estimated price
$22 - $230
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Chicago Union Station to Milwaukee Intermodal Station
Ave. Duration
1h 29m
Frequency
Every 4 hours
Estimated price
$27 - $40
Website
amtrak.com
Coach Seat
$27 - $40
Premium
$180 - $260
Flexi Coach Seat
$40 - $60
Business Seat
$35 - $55
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5h 30m
Frequency
5 times a day
Estimated price
$40 - $60
Website
amtrak.com
Coach Seat
$40 - $60
Premium
$210 - $300
Flexi Coach Seat
$75 - $110
Business Seat
$75 - $110
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Greyhound Bus Station St. Louis
Ave. Duration
6h 40m
Frequency
Every 4 hours
Estimated price
$35 - $55
Website
greyhound.com
Economy
$35 - $55
Flexible
$60 - $90
Megabus

Want to know more about travelling around United States

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More Questions & Answers

The quickest flight from Chicago Midway Airport to St. Louis Airport is the direct flight which takes 1h.

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Chicago to St. Louis bus services, operated by Greyhound USA, arrive at Greyhound Bus Station St. Louis.

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Chicago to St. Louis train services, operated by Amtrak, arrive at St. Louis Gateway Station.

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Yes, the driving distance between Chicago to St. Louis is 297 miles. It takes approximately 4h 53m to drive from Chicago to St. Louis.

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Southwest Airlines offers flights from Chicago Midway Airport to St. Louis Airport.

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Book your Chicago to St. Louis train tickets online with Omio.

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Book your Chicago to St. Louis bus tickets online with Greyhound.

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There are 310+ hotels available in St. Louis. Prices start at $100 USD per night.

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The best way to get from Chicago to Chicago Midway Airport is to subway which takes 23 min and costs $2 - $5.

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