The average bus between Buffalo and Middlesex takes 10h 26m and the fastest bus takes 9h 40m. The bus service runs several times per day from Buffalo to Middlesex. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Buffalo and Middlesex. The earliest departure is at 6:00 AM in the morning, and the last departure from Buffalo is at 11:15 PM which arrives into Middlesex at 8:55 AM. All services require a transfer at New York and take an average of 10h 26m. The schedules shown below are for the next available departures.

11h 6m • 1 change

11h 3m • 1 change
Arrives next day

10h 29m • 1 change
Arrives next day

10h 31m • 1 change

10h 55m • 1 change

11h • 1 change
Arrives next day

10h 15m • 1 change
Arrives next day

9h 40m • 1 change

10h 34m • 1 change

10h 45m • 1 change
Arrives next day

10h 18m • 1 change
Arrives next day

9h 40m • 1 change

10h 45m • 1 change
Arrives next day

10h 18m • 1 change
Arrives next day

9h 40m • 1 change

10h 45m • 1 change
Arrives next day

10h 18m • 1 change
Arrives next day

9h 40m • 1 change
Want to know about travelling from Buffalo to Middlesex? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Buffalo to Middlesex. However, there are services departing from Buffalo station and arriving at Middlesex station via New York. The journey, including transfers, takes approximately 10h 26m.
Buffalo to Middlesex bus services, operated by Trailways, depart from Buffalo station.
Buffalo to Middlesex bus services, operated by Trailways, arrive at Boundbrook Rd At John F. Kennedy Dr station.
The distance between Buffalo and Middlesex is 445.5 km. The road distance is 878 km.
You can take a bus from Buffalo to Boundbrook Rd At John F. Kennedy Dr via New York and Port Authority Bus Terminal in around 10h 11m.