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Buffalo to Chicago Loop buses

Find Transport to Chicago Loop

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Trip Overview

The average bus between Buffalo and Chicago Loop takes 12h 44m and the fastest bus takes 12h 9m. The bus service runs several times per day from Buffalo to Chicago Loop. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 44m
Duration
545 mi
Distance
$120
Average price
Twice daily
Frequency

Buffalo to Chicago Loop bus times

Buses run twice daily between Buffalo and Chicago Loop. The earliest departure is at 7:55 AM in the morning, and the last departure from Buffalo is at 11:05 PM which arrives into Chicago Loop at 10:14 AM. All services require a transfer at Cleveland Bus Station and take an average of 12h 44m. The schedules shown below are for the next available departures.

Departing Sunday, October 25, 2026

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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Monday, October 26, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Tuesday, October 27, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Wednesday, October 28, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Thursday, October 29, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Friday, October 30, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 13m • 2 changes

Departing Saturday, October 31, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 22m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 12m • 2 changes

Frequently asked questions

Want to know about travelling from Buffalo to Chicago Loop? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Chicago Loop.ExpandLaunch map view
  • Distance: 545.2 mi
  • Duration: 12h 44m

What companies run services between Buffalo, NY, USA and Chicago Loop, IL, USA?

You can take a bus from Buffalo to Washington & Lasalle via Cleveland Bus Station, Chicago Bus Station, and Jefferson & Harrison in around 11h 52m.

Operators