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Buffalo to Chicago Loop buses

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Trip Overview

The average bus between Buffalo and Chicago Loop takes 12h 47m and the fastest bus takes 12h 7m. The bus service runs several times per day from Buffalo to Chicago Loop. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 47m
Duration
545 mi
Distance
$115
Average price
Twice daily
Frequency

Buffalo to Chicago Loop bus times

Buses run twice daily between Buffalo and Chicago Loop. The earliest departure is at 7:55 AM in the morning, and the last departure from Buffalo is at 11:05 PM which arrives into Chicago Loop at 10:12 AM. All services require a transfer at Cleveland Bus Station and take an average of 12h 47m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 7m • 2 changes

Departing Sunday, November 15, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 29m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Monday, November 16, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Tuesday, November 17, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Wednesday, November 18, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Thursday, November 19, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 9m • 2 changes

Departing Friday, November 20, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 25m • 2 changes
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    Arrives next day

    Greyhound USAGreyhound USAChicago Transit (CTA)12h 13m • 2 changes

Departing Saturday, November 21, 2026

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    Greyhound USAGreyhound USAChicago Transit (CTA)13h 22m • 2 changes

Frequently asked questions

Want to know about travelling from Buffalo to Chicago Loop? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Chicago Loop.ExpandLaunch map view
  • Distance: 545.2 mi
  • Duration: 12h 47m

What companies run services between Buffalo, NY, USA and Chicago Loop, IL, USA?

You can take a bus from Buffalo to Washington & Lasalle via Cleveland Bus Station, Chicago Bus Station, and Jefferson & Harrison in around 11h 52m.

Operators