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How to get fromBuffalo to Middlesexby plane, train, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

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There are 10 ways to get from Buffalo to Middlesex by plane, train, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Newark Liberty International Airport, train

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Newark Liberty International Airport (EWR)plane plane BUF - EWR
    2. Take the train from Newark Penn Station to Dunellentrain train
    5h 6m
    $49–318

  2. Bus

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus Greyhound US0205 / ...
    2. Take the bus from Port Authority Bus Terminal to Boundbrook Rd At John F. Kennedy Drbus bus 114
    10h 21m
    $68–283

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    10h 32m
    $250–943

  4. Drive  338.5 mi

    1. Drive from Buffalo to Middlesexcar car 338.5 mi
    7h 4m
    $62–90

  5. Fly Buffalo Niagara International Airport to Laguardia Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Laguardia Airport (LGA)plane plane BUF - LGA
    2. Take the train from Woodside to New York Penn Stationtrain train
    3. Take the train from New York Penn Station to Newark Penn Stationtrain train
    4. Take the train from Newark Penn Station to Dunellentrain train
    5h 50m
    $83–521

  6. Fly Buffalo Niagara International Airport to John F. Kennedy International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to John F. Kennedy International Airport (JFK)plane plane BUF - JFK
    2. Take the train from Jamaica to New York Penn Stationtrain train
    3. Take the train from New York Penn Station to Newark Penn Stationtrain train
    4. Take the train from Newark Penn Station to Dunellentrain train
    5h 42m
    $64–324

  7. Bus to Rochester, fly to Newark Liberty International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Newark Liberty International Airport (EWR)plane plane ROC - EWR
    6h 12m
    $92–449

  8. Fly Buffalo Niagara International Airport to Philadelphia International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Philadelphia International Airport (PHL)plane plane BUF - PHL
    2. Take the train from 30th Street Station to Newark Penn Stationtrain train
    3. Take the train from Newark Penn Station to Dunellentrain train
    6h 39m
    $87–1,036

  9. Bus via New York

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from Port Authority Bus Terminal to Boundbrook Rd At John F. Kennedy Drbus bus 114
    10h 52m
    $77–132

  10. Train, bus

    1. Take the train from Buffalo to New York Penn Stationtrain train VIA Rail
    2. Take the bus from Port Authority Bus Terminal to Boundbrook Rd At John F. Kennedy Drbus bus 114
    11h 31m
    $128–315

Buffalo to Middlesex by bus

Calendar57Weekly Buses
Duration10h 21mAverage Duration
Ticket$68Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Middlesex.ExpandLaunch map view
  • Distance: 320.9 mi
  • Duration: 5h 6m

What companies run services between Buffalo, NY, USA and Middlesex, NJ, USA?

You can take a bus from Buffalo to Boundbrook Rd At John F. Kennedy Dr via Port Authority Bus Terminal in around 10h 21m. Alternatively, Amtrak operates a train from Buffalo to Ny Moynihan Train Hall At Penn Station 3 times a day. Tickets cost $240–380 and the journey takes 8h 17m.

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