Rome2Rio

Buffalo to Key Largo buses

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Trip Overview

The average bus between Buffalo and Key Largo takes 46h 47m and the fastest bus takes 43h 55m. The bus runs, on average, 4 times per week from Buffalo to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

46h 47m
Duration
1,779 mi
Distance
$348
Average price
4 times a week
Frequency

Buffalo to Key Largo bus times

Buses run 4 times a week between Buffalo and Key Largo. The service departs Buffalo at 10:30 AM in the morning, which arrives into Key Largo at 06:25:00. All services require a transfer at Newark Penn Station and take an average of 46h 47m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USA43h 55m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USA43h 55m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USA43h 55m • 2 changes

Frequently asked questions

Want to know about travelling from Buffalo to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Key Largo.ExpandLaunch map view
  • Distance: 1,778.8 mi
  • Duration: 46h 47m

What companies run services between Buffalo, NY, USA and Key Largo, FL, USA?

You can take a bus from Buffalo to Key Largo Bus Stop via Newark Penn Station and Miami Airport Station in around 36h 35m.

Operators