The average bus between Kissimmee and Key Largo takes 11h 23m and the fastest bus takes 7h 5m. The bus service runs several times per day from Kissimmee to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Kissimmee and Key Largo. The earliest departure is at 5:05 AM in the morning, and the last departure from Kissimmee is at 10:10 PM which arrives into Key Largo at 9:20 AM. All services require a transfer at Florida Mall Ave & Crystal Clear Ln and take an average of 11h 23m. The schedules shown below are for the next available departures.


7h 15m • 2 changes
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12h 15m • 2 changes
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11h 20m • 2 changes


7h 10m • 2 changes
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13h 45m • 2 changes
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11h 10m • 2 changes


7h 5m • 2 changes
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12h 15m • 2 changes
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12h • 2 changes


7h 15m • 2 changes
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12h 15m • 2 changes
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11h 20m • 2 changes
Want to know about travelling from Kissimmee to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Kissimmee to Key Largo. However, there are services departing from Kissimmee station and arriving at Key Largo station via Miami Airport Station station. The journey, including transfers, takes approximately 11h 23m.
Kissimmee to Key Largo bus services, operated by Lynx Central Florida Transport, depart from Orlando station.
Kissimmee to Key Largo bus services, operated by Lynx Central Florida Transport, arrive at Key Largo Bus Stop station.
The distance between Kissimmee and Key Largo is 370.5 km. The road distance is 475 km.
You can take a bus from Pleasant St & Neptune Rd to Key Largo Bus Stop via Florida Mall Ave & Crystal Clear Ln, Orlando, and Miami Airport Station in around 8h 19m.