The average bus between Kissimmee and Key Largo takes 12h 47m and the fastest bus takes 7h 10m. The bus service runs several times per day from Kissimmee to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Kissimmee and Key Largo. The earliest departure is at 5:05 AM in the morning, and the last departure from Kissimmee is at 10:10 PM which arrives into Key Largo at 9:20 AM. All services require a transfer at Osceola Pkwy Walmart and take an average of 12h 47m. The schedules shown below are for the next available departures.
Arrives next day


19h 35m • 2 changes
Arrives next day


14h 20m • 2 changes
Arrives next day


16h 15m • 2 changes
Arrives next day


11h 20m • 2 changes
Want to know about travelling from Kissimmee to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Kissimmee to Key Largo. However, there are services departing from Kissimmee station and arriving at Key Largo station via Sheridan Tri-Rail Station station. The journey, including transfers, takes approximately 12h 47m.
Kissimmee to Key Largo bus services, operated by Lynx Central Florida Transport, depart from Kissimmee -1471 East Osceola Parkway station.
Kissimmee to Key Largo bus services, operated by Lynx Central Florida Transport, arrive at Key Largo Bus Stop station.
Book your Kissimmee to Key Largo bus tickets online with Lynx Central Florida Transport, Flixbus USA and Greyhound USA.
The distance between Kissimmee and Key Largo is 370.5 km. The road distance is 455 km.
You can take a bus from E Vine St & Brack St to Key Largo Bus Stop via Osceola Pkwy Walmart, Kissimmee -1471 East Osceola Parkway, Sheridan Tri-Rail Station, Sheridan Street Station, Miami, Airport Intermodal Station, and Miami Airport Station in around 8h 6m.