The average bus between Tampa and Key Largo takes 13h 37m and the fastest bus takes 10h 45m. The bus service runs several times per day from Tampa to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Tampa and Key Largo. The earliest departure is at 1:45 PM in the afternoon, and the last departure from Tampa is at 10:35 PM which arrives into Key Largo at 12:20 PM. All services require a transfer, and take on average 13h 37m. The schedules shown below are for the next available departures.
Arrives next day

15h 10m • 1 change
Arrives next day

10h 45m • 1 change
Arrives next day

15h 10m • 1 change
Arrives next day

10h 45m • 1 change
Arrives next day

15h 10m • 1 change
Arrives next day

10h 45m • 1 change
Arrives next day

15h 10m • 1 change
Arrives next day

10h 45m • 1 change
Want to know about travelling from Tampa to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Tampa to Key Largo. However, there are services departing from Tampa station and arriving at Key Largo station via Miami Airport Station station. The journey, including transfers, takes approximately 13h 37m.
Tampa to Key Largo bus services, operated by Flixbus USA, depart from Tampa Bus Station.
Tampa to Key Largo bus services, operated by Flixbus USA, arrive at Key Largo Bus Stop station.
Book your Tampa to Key Largo bus tickets online with Flixbus USA and Greyhound USA.
The distance between Tampa and Key Largo is 375.8 km. The road distance is 563 km.
You can take a bus from Tampa Bus Station to Key Largo Bus Stop via Miami Airport Station in around 8h 40m.