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Fort Myers to Key Largo buses

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Trip Overview

The average bus between Fort Myers and Key Largo takes 13h 18m and the fastest bus takes 11h 55m. There is at least one bus per day from Fort Myers to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

13h 18m
Duration
216 mi
Distance
$44
Average price
Once daily
Frequency

Fort Myers to Key Largo bus times

Buses run once daily between Fort Myers and Key Largo. The earliest departure is at 4:45 PM in the afternoon, and the last departure from Fort Myers is at 6:30 PM which arrives into Key Largo at 6:25 AM. All services require a transfer, and take on average 13h 18m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

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    Arrives next day

    Flixbus USAGreyhound USA11h 55m • 1 change

Departing Monday, November 16, 2026

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    Arrives next day

    Flixbus USAGreyhound USA11h 55m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA11h 55m • 1 change

Departing Wednesday, November 18, 2026

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    Arrives next day

    Flixbus USAGreyhound USA13h 40m • 1 change

Departing Thursday, November 19, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA11h 55m • 1 change

Departing Friday, November 20, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA11h 55m • 1 change

Frequently asked questions

Want to know about travelling from Fort Myers to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Fort Myers to Key Largo.ExpandLaunch map view
  • Distance: 216.3 mi
  • Duration: 13h 18m

What companies run services between Fort Myers, FL, USA and Key Largo, FL, USA?

You can take a bus from Fort Myers Bus Stop to Key Largo Bus Stop via Miami Airport Station in around 5h 25m.

Operators