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How to get fromSanta Ana to Key Westby plane, bus (Greyhound), train, bus, ferry or car

Find Transport to Key West

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There are 7 ways to get from Santa Ana to Key West by plane, bus (Greyhound), train, bus, ferry, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Key West International Airport (EYW)plane plane SNA - EYW
    7h 29m
    $259–946

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Santa Ana to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Key West International Airport (EYW)plane plane LAX - EYW
    9h 41m
    $196–787

  3. Bus

    1. Take the bus from Santa Ana to El Pasobus bus
    2. Take the bus from El Paso to Houstonbus bus
    3. Take the bus from Houston to Del Carmen Mexican Store - Dade City, FLbus bus
    4. Take the bus from Dade City to Miamibus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    6. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus
    2d 14h
    $482–868

  4. Train, bus, ferry

    1. Take the train from Santa Ana to Los Angelestrain train
    2. Take the train from Los Angeles to Houstontrain train
    3. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus bus
    4. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    2d 16h
    $804–1,439

  5. Drive 2,815.9 mi

    1. Drive from Santa Ana to Key Westcar car 2,815.9 mi
    47h 9m
    $514–743

  6. Train to San Diego International Airport, fly

    1. Take the train from Santa Ana to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Key West International Airport (EYW)plane plane SAN - EYW
    9h 55m
    $255–1,016

  7. Train, bus, ferry via Irving

    1. Take the train from Santa Ana to L.A. Union Stationtrain train
    2. Take the bus from Los Angeles Union Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to Houston Bus Stationbus bus
    4. Take the bus from Houston - Harrisburg Blvd to Fort Myersbus bus
    5. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    2d 15h
    $618–941

John Wayne Airport Orange County (SNA) to Key West International Airport (EYW) flights

Calendar30Weekly Planes
Duration8h 47mAverage Duration
Ticket$221Cheapest Price
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Questions & Answers

What companies run services between Santa Ana, CA, USA and Key West, FL, USA?

American Airlines and Delta fly from John Wayne Airport Orange County (SNA) to Key West International Airport (EYW) 4 times a day. Alternatively, you can take a bus from Santa Ana to N Roosevelt & 3rd Street via El Paso, El Paso, Houston, Dade City, Miami, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 2d 14h.

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