There are 8 ways to get from Iowa to Key West by plane, bus (Flixbus, Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Des Moines
best- Fly from Des Moines (DSM) to Key West International Airport (EYW)DSM - EYW
5h 16m$239–1,034Fly from Quad City International Airport
cheapest- Fly from Quad City International Airport (MLI) to Key West International Airport (EYW)MLI - EYW
6h 59m$133–615Bus
- Take the bus from Des Moines to Champaign
- Take the bus from Champaign Intermodal Trans Ctr to Atlanta Bus Station
- Take the bus from Atlanta Bus Station to Miami Airport Station
- Take the bus from Miami Airport Station to Big Pine Key
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd StreetLks
44h 26m$254–562Bus, train
- Take the bus from Des Moines to Chicago
- Take the train from Chicago Union Station to Miami Amtrak Station
- Take the bus from Miami Airport Station to Big Pine Key
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd StreetLks
2d 13h$353–977Drive 1,679.3 mi
- Drive from Des Moines to Key West1,679.3 mi
30h 2m$307–443Fly from The Eastern Iowa Airport
- Fly from The Eastern Iowa Airport (CID) to Key West International Airport (EYW)CID - EYW
7h$153–653Fly from Waterloo Municipal Airport
- Fly from Waterloo Municipal Airport (ALO) to Key West International Airport (EYW)ALO - EYW
6h 19m$160–685Fly from Omaha
- Fly from Omaha (OMA) to Key West International Airport (EYW)OMA - EYW
8h 24m$244–1,116
Iowa to Key West by bus and foot
Questions & Answers
The cheapest way to get from Iowa to Key West is to fly which costs $130 - $650 and takes 6h 59m.
The fastest way to get from Iowa to Key West is to fly which takes 5h 16m and costs $230 - $1,100.
No, there is no direct bus from Iowa to Key West. However, there are services departing from Des Moines and arriving at N Roosevelt & 3rd Street via Champaign Intermodal Trans Ctr, Atlanta Bus Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 44h 26m.
The distance between Iowa and Key West is 1374 miles. The road distance is 1689.1 miles.
The best way to get from Iowa to Key West without a car is to bus which takes 44h 26m and costs $250 - $600.
It takes approximately 5h 16m to get from Iowa to Key West, including transfers.
Iowa to Key West bus services, operated by Burlington Trailways, depart from Des Moines station.
The best way to get from Iowa to Key West is to fly which takes 5h 16m and costs $230 - $1,100. Alternatively, you can bus, which costs $250 - $600 and takes 44h 26m.
Iowa to Key West bus services, operated by Burlington Trailways, arrive at Champaign station.
Key West is 1h ahead of Iowa. It is currently 5:57 PM in Iowa and 6:57 PM in Key West.
What companies run services between Iowa, USA and Key West, FL, USA?
Delta, United Airlines, and two other airlines fly from Des Moines (DSM) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Des Moines to N Roosevelt & 3rd Street via Champaign, Champaign Intermodal Trans Ctr, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 44h 26m.
- Website
- aa.com
Flights from Des Moines to Key West International Airport via Miami
- Ave. Duration
- 6h 13m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- $220–1,100
Flights from Des Moines to Key West International Airport via Charlotte
- Ave. Duration
- 7h 9m
- When
- Every day
- Estimated price
- $240–1,100
Flights from Des Moines to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 8h 8m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,100
Flights from The Eastern Iowa Airport to Key West International Airport via Miami
- Ave. Duration
- 6h 26m
- When
- Saturday
- Estimated price
- $130–600
Flights from The Eastern Iowa Airport to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 6h 27m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $130–600
Flights from The Eastern Iowa Airport to Key West International Airport via Charlotte
- Ave. Duration
- 6h 34m
- When
- Every day
- Estimated price
- $130–650
Flights from The Eastern Iowa Airport to Key West International Airport via Dallas/Ft.Worth
- Ave. Duration
- 10h 29m
- When
- Every day
- Estimated price
- $150–700
Flights from Waterloo Municipal Airport to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 8h 39m
- When
- Every day
- Estimated price
- $130–650
Flights from Quad City International Airport to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $130–600
Flights from Quad City International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 6h 14m
- When
- Every day
- Estimated price
- $130–600
Flights from Quad City International Airport to Key West International Airport via Dallas/Ft.Worth
- Ave. Duration
- 9h 10m
- When
- Every day
- Estimated price
- $150–700
Flights from Omaha to Key West International Airport via Miami
- Ave. Duration
- 6h 13m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,100
Flights from Omaha to Key West International Airport via Charlotte
- Ave. Duration
- 7h 22m
- When
- Every day
- Estimated price
- $250–1,100
- Website
- delta.com
Flights from Des Moines to Key West International Airport via Atlanta
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $220–1,000
Flights from The Eastern Iowa Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 20m
- When
- Every day
- Estimated price
- $120–600
Flights from Quad City International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 17m
- When
- Every day
- Estimated price
- $120–600
Flights from Omaha to Key West International Airport via Atlanta
- Ave. Duration
- 6h 46m
- When
- Every day
- Estimated price
- $230–1,100
- Website
- allegiantair.com
Flights from Des Moines to Key West International Airport via St. Petersburg
- Ave. Duration
- 7h 24m
- When
- Wednesday
- Estimated price
- $210–1,000
Flights from The Eastern Iowa Airport to Key West International Airport via St. Petersburg
- Ave. Duration
- 11h 23m
- When
- Sunday
- Estimated price
- $120–600
Flights from Quad City International Airport to Key West International Airport via Orlando Sanford
- Ave. Duration
- 4h 41m
- When
- Tuesday
- Estimated price
- $120–600
Flights from Quad City International Airport to Key West International Airport via St. Petersburg
- Ave. Duration
- 6h 6m
- When
- Tuesday
- Estimated price
- $120–600
Flights from Omaha to Key West International Airport via St. Petersburg
- Ave. Duration
- 10h 45m
- When
- Monday, Friday, and Sunday
- Estimated price
- $230–1,100
- Website
- united.com
Flights from Des Moines to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 6h 12m
- When
- Every day
- Estimated price
- $240–1,100
Flights from The Eastern Iowa Airport to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 6h 12m
- When
- Every day
- Estimated price
- $130–600
Flights from Waterloo Municipal Airport to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 8h 32m
- When
- Every day
- Estimated price
- $130–650
Flights from Quad City International Airport to Key West International Airport via Chicago O'Hare
- Ave. Duration
- 7h 42m
- When
- Every day
- Estimated price
- $130–600
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Miami Amtrak Station
- Ave. Duration
- 46h 29m
- Frequency
- Once daily
- Estimated price
- $250–750
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (319) 753-2864
- info@burlingtontrailways.com
- Website
- burlingtontrailways.com
Bus from Des Moines to Champaign
- Ave. Duration
- 7h 20m
- Frequency
- Once daily
- Estimated price
- $65–130
- Website
- https://burlingtontrailways.com
- Saver Fares
- $65–95
- Flexible Fares
- $90–130
Bus from Des Moines to Chicago
- Ave. Duration
- 7h 15m
- Frequency
- Twice daily
- Estimated price
- $55–160
- Website
- https://burlingtontrailways.com
- Saver Fares
- $65–100
- Flexible Fares
- $90–140
- Saver Fare
- $55–110
- Flex Fare
- $75–160
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Champaign Intermodal Trans Ctr to Atlanta Bus Station
- Ave. Duration
- 14h 10m
- Frequency
- Once daily
- Estimated price
- $100–190
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 14h 5m
- Frequency
- Once daily
- Estimated price
- $65–200
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $21–40
- Website
- https://www.greyhound.com/
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
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More Questions & Answers
Yes, the driving distance between Iowa to Key West is 1689 miles. It takes approximately 30h 2m to drive from Iowa to Key West.
There are 799+ hotels available in Key West.










