Silver Airways flies from Cape Coral to Key West once daily.
How to get from Cape Coral to Key West
From Cape Coral taxi to Fort Myers Beach, FL then ferry to Key West, FL. 3 h 46 min $133. From Cape Coral drive to Key West. 5 h 49 min $35. From Cape Coral Parkway @ Vincennes Street line 30 bus to Bell Tower Shops @ Bell Tower Shops Avenue, line 50 bus to Ft. Myers airport, fly to Key West airport, then bus to Key West. 4 h 53 min $169.