There are 9 ways to get from Sicily to Isernia by plane, train, ferry, car, bus, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Catania–Fontanarossa Airport to Naples Airport, train
best- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Napoli Centrale to Iserniatrain
5h 36m€33–132Bus
cheapest- Take the bus from Palermo Terminal Bus to Napoli, Autostazione Metroparkbus Itabus
- Take the bus from Napoli, Autostazione Metropark to Iserniabus 6
14h 50m€29–46Ferry, drive
- Take the ferry from Port of Palermo to Naples Beverelloferry
- Drive from Naples Beverello to Iserniacar
12h 5m€57–90Bus via Caserta
- Take the bus from Palermo Via Tommaso Fazello to Caserta Viale Vittorio Venetobus Autoservizi Salemi S202
- Take the bus from Caserta Terminal Bus to Iserniabus 433
13h 24m€36–62Train (Trenitalia)
- Take the train from Palermo Centrale to Napoli Centraletrain Ic
- Take the train from Napoli Centrale to Iserniatrain Re
13h 30m€31–106Fly Palermo Airport to Naples Airport, train
- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Napoli Centrale to Iserniatrain
5h 59m€34–134Fly Vincenzo Magliocco Airport to Fiumicino International Airport, train
- Fly from Vincenzo Magliocco Airport (CIY) to Fiumicino International Airport (FCO)plane CIY - FCO
- Take the train from Roma Termini to Iserniatrain
5h 20m€85–235Fly Catania–Fontanarossa Airport to Fiumicino International Airport, train
- Fly from Catania–Fontanarossa Airport (CTA) to Fiumicino International Airport (FCO)plane CTA - FCO
- Take the train from Roma Termini to Iserniatrain
6h 16m€53–196Fly Palermo Airport to Fiumicino International Airport, train
- Fly from Palermo Airport (PMO) to Fiumicino International Airport (FCO)plane PMO - FCO
- Take the train from Roma Termini to Iserniatrain
6h 44m€55–208
Sicily to Isernia by bus
Questions & Answers
The cheapest way to get from Sicily to Isernia is to bus which costs €29 - €50 and takes 14h 50m.
The fastest way to get from Sicily to Isernia is to fly and train which takes 5h 20m and costs €80 - €240.
No, there is no direct bus from Sicily to Isernia. However, there are services departing from Piazza Boiardo and arriving at Isernia via Palermo Via Tommaso Fazello and Caserta Terminal Bus. The journey, including transfers, takes approximately 13h 24m.
No, there is no direct train from Sicily to Isernia. However, there are services departing from Palermo Notarbartolo and arriving at Isernia via Palermo Centrale and Napoli Centrale. The journey, including transfers, takes approximately 13h 30m.
The distance between Sicily and Isernia is 520 km.
The best way to get from Sicily to Isernia without a car is to bus via Caserta which takes 13h 24m and costs €35 - €65.
It takes approximately 5h 36m to get from Sicily to Isernia, including transfers.
Sicily to Isernia bus services, operated by Autoservizi Salemi Srl, depart from Palermo Via Tommaso Fazello station.
Sicily to Isernia train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Sicily to Isernia is to bus via Caserta which takes 13h 24m and costs €35 - €65. Alternatively, you can train, which costs €30 - €110 and takes 13h 30m.
What companies run services between Sicily, Italy and Isernia, Italy?
You can take a bus from Piazza Boiardo to Isernia via Stazione Centrale Pensilina Esterna, Palermo Via Tommaso Fazello, Caserta Viale Vittorio Veneto, and Caserta Terminal Bus in around 13h 24m. Alternatively, you can take a train from Palermo Notarbartolo to Isernia via Palermo Centrale and Napoli Centrale in around 13h 30m.
- Website
- ryanair.com
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €30–120
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €40–110
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €24–120
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport via Malta
- Ave. Duration
- 3h 30m
- When
- Monday and Saturday
- Estimated price
- €24–120
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €28–140
- Website
- aeroitalia.com
Flights from Vincenzo Magliocco Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €45–260
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €30–130
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €30–210
- Website
- flexflight.dk
Flights from Vincenzo Magliocco Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €45–260
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €30–130
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €30–210
- Website
- ita-airways.com
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €35–110
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- €35–120
- Website
- easyjet.com
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- €21–95
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 54 min
- When
- Every day
- Estimated price
- €20–90
- Website
- volotea.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €20–90
- Website
- neosair.it
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 20m
- When
- Sunday
- Estimated price
- €150–410
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €8–14
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €13–55
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Napoli Centrale
- Ave. Duration
- 9h 10m
- Frequency
- Once daily
- Estimated price
- €21–90
- Website
- https://www.trenitalia.com/en.html
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo Via Tommaso Fazello to Caserta Viale Vittorio Veneto
- Ave. Duration
- 9h 50m
- Frequency
- Once daily
- Estimated price
- €30–45
- Schedules at
- autoservizisalemi.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Caserta Terminal Bus to Isernia
- Ave. Duration
- 1h 14m
- Frequency
- Once daily
- Estimated price
- €5–16
- Website
- https://www.flixbus.co.uk
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Palermo Terminal Bus to Napoli, Autostazione Metropark
- Ave. Duration
- 10h 40m
- Frequency
- 3 times a week
- Estimated price
- €24–35
- Website
- https://www.itabus.it/en/home
- Phone
- 0865.221788
- info@satiautobus.com
- Website
- satiautobus.com
Bus from Napoli, Autostazione Metropark to Isernia
- Ave. Duration
- 1h 50m
- Frequency
- 3 times a day
- Estimated price
- €4–10
- Schedules at
- satiautobus.com
- Phone
- 02 76028132
- helpdesk@tirrenia.it
- Website
- tirrenia.it
Ferry from Port of Palermo to Naples Beverello
- Ave. Duration
- 10h 30m
- Frequency
- Once daily
- Estimated price
- €40–65
- Website
- https://www.tirrenia.it/
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More Questions & Answers
Sicily to Isernia bus services, operated by Autoservizi Salemi Srl, arrive at Caserta Viale Vittorio Veneto station.
Sicily to Isernia train services, operated by Trenitalia Intercity, arrive at Napoli Centrale station.
Book your Sicily to Isernia train tickets online with Omio.
There are 435+ hotels available in Isernia.

















