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How to get fromMyrtle Beach to Florida KeysBy plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

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There are 6 ways to get from Myrtle Beach to Florida Keys by plane, bus, train, bus (Greyhound, Flixbus), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Myrtle Beach to Key West International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    7h 24m
    $184–608

  2. Drive 818.9 mi

    cheapest
    1. Drive from Myrtle Beach to Florida Keyscar car 818.9 mi
    14h 58m
    $150–216

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 7m
    $211–470

  4. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    29h 35m
    $171–365

  5. Fly Myrtle Beach to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 57m
    $239–868

  6. Bus to Wilmington International Airport, fly to Key West International Airport

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Key West International Airport (EYW)plane plane ILM - EYW
    9h 41m
    $193–635

Myrtle Beach to Florida Keys by bus, train, and foot

Calendar7Weekly Services
Duration24h 7mAverage Duration
Ticket$211Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Myrtle Beach (MYR) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Florida Keys via Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 29h 35m.

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