Rome2Rio

How to get fromMyrtle Beach to Florida Keysby plane, bus (Greyhound, Flixbus), bus, train, car or shuttle

Find Transport to Florida Keys

See all options

There are 5 ways to get from Myrtle Beach to Florida Keys by plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    7h 34m
    $357–501

  2. Bus, train

    cheapest
    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 2m
    $113–334

  3. Bus

    1. Take the bus from Myrtle Beach, SC to Florencebus bus
    2. Take the bus from Florence Bus Station to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    23h 7m
    $137–443

  4. Drive 818.9 mi

    1. Drive from Myrtle Beach to Florida Keyscar car 818.9 mi
    14h 58m
    $150–216

  5. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 57m
    $217–456

Myrtle Beach to Florida Keys by bus and foot

Calendar7Weekly Services
Duration23h 7mAverage Duration
Ticket$137Cheapest Price
See schedules

Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Myrtle Beach (MYR) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Myrtle Beach, SC to Florida Keys via Florence, Florence Bus Station, Orlando Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 23h 7m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Myrtle Beach

Trips to Florida Keys

Popular routes