There are 8 ways to get from Buffalo to Florida Keys by plane, bus, train, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Buffalo Niagara International Airport to Key West International Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW)plane BUF - EYW
9h 33m$271–1,249Bus to Rochester, fly to Key West International Airport
cheapest- Take the bus from Buffalo, NY to Rochester, NYbus
- Fly from Rochester (ROC) to Key West International Airport (EYW)plane ROC - EYW
12h 22m$251–1,104Bus, train via Newark
- Take the bus from Buffalo to Newark Penn Stationbus
- Take the train from Newark Penn Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
43h 4m$261–843Drive 1,521.1 mi
- Drive from Buffalo to Florida Keyscar 1,521.1 mi
26h 9m$278–401Fly Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Buffalo Niagara International Airport (BUF) to Fort Lauderdale–Hollywood International Airport (FLL)plane BUF - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
10h 25m$266–884Shuttle to Toronto Pearson International Airport, fly to Key West International Airport
- Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1
- Fly from Toronto Pearson International Airport (YYZ) to Key West International Airport (EYW)plane YYZ - EYW
12h 47m$391–689Train, bus
- Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
44h 9m$262–925Bus, train
- Take the bus from Buffalo to Pittsburghbus
- Take the train from Pittsburgh Amtrak Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
2d 3h$252–728
Buffalo to Florida Keys by bus, train, taxi, and foot
Questions & Answers
The cheapest way to get from Buffalo to Florida Keys is to drive which costs $270 - $410 and takes 26h 9m.
The fastest way to get from Buffalo to Florida Keys is to fly which takes 9h 33m and costs $270 - $1,300.
The distance between Buffalo and Florida Keys is 1321 miles. The road distance is 1530 miles.
The best way to get from Buffalo to Florida Keys without a car is to bus and train via Newark which takes 43h 4m and costs $260 - $850.
It takes approximately 9h 33m to get from Buffalo to Florida Keys, including transfers.
Yes, the driving distance between Buffalo to Florida Keys is 1530 miles. It takes approximately 26h 9m to drive from Buffalo to Florida Keys.
There are 739+ hotels available in Florida Keys.
What companies run services between Buffalo, NY, USA and Florida Keys, FL, USA?
American Airlines, Delta, and three other airlines fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW) 5 times a day.
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 7h 15m
- When
- Every day
- Estimated price
- $220–1,100
Flights from Buffalo Niagara International Airport to Key West International Airport via Reagan Washington
- Ave. Duration
- 10h 51m
- When
- Saturday and Sunday
- Estimated price
- $230–1,200
Flights from Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport via Charlotte
- Ave. Duration
- 5h 28m
- When
- Every day
- Estimated price
- $110–600
Flights from Rochester to Key West International Airport via Miami
- Ave. Duration
- 6h 11m
- When
- Saturday
- Estimated price
- $180–900
Flights from Rochester to Key West International Airport via Charlotte
- Ave. Duration
- 8h 14m
- When
- Every day
- Estimated price
- $180–900
Flights from Toronto Pearson International Airport to Key West International Airport via Miami
- Ave. Duration
- 6h 13m
- When
- Every day
- Estimated price
- $120–650
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 3h 10m
- When
- Saturday
- Estimated price
- $110–600
Flights from Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport via Orlando
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $110–600
Flights from Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport via Baltimore
- Ave. Duration
- 5h 43m
- When
- Every day
- Estimated price
- $120–600
Flights from Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport via Tampa
- Ave. Duration
- 5h 30m
- When
- Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $120–600
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 6h 54m
- When
- Every day
- Estimated price
- $230–1,200
Flights from Rochester to Key West International Airport via Atlanta
- Ave. Duration
- 7h 13m
- When
- Every day
- Estimated price
- $190–950
Flights from Toronto Pearson International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 7h 29m
- When
- Every day
- Estimated price
- $130–650
- Website
- spirit.com
Flights from Buffalo Niagara International Airport to Key West International Airport via Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 5h 56m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $230–1,200
Flights from Toronto Pearson International Airport to Key West International Airport via Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 5h 26m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $120–650
- Website
- jetblue.com
Flights from Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 3h 11m
- When
- Every day
- Estimated price
- $110–600
- Website
- flybreeze.com
Flights from Toronto Pearson International Airport to Key West International Airport via Orlando
- Ave. Duration
- 5h 11m
- When
- Monday and Friday
- Estimated price
- $240–1,000
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Newark Penn Station to Miami Amtrak Station
- Ave. Duration
- 28h 6m
- Frequency
- Once daily
- Estimated price
- $160–650
- Website
- https://www.amtrak.com/home.html
Train from Buffalo to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 8h 27m
- Frequency
- 3 times a day
- Estimated price
- $60–160
- Website
- https://www.amtrak.com/home.html
Train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Station
- Ave. Duration
- 28h 29m
- Frequency
- Once daily
- Estimated price
- $150–700
- Website
- https://www.amtrak.com/home.html
Train from Pittsburgh Amtrak Station to Miami Amtrak Station
- Ave. Duration
- 36h 49m
- Frequency
- Once daily
- Estimated price
- $160–480
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Buffalo to Newark Penn Station
- Ave. Duration
- 7h 45m
- Frequency
- 5 times a day
- Estimated price
- $50–120
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Buffalo to Newark Penn Station
- Ave. Duration
- 8h 15m
- Frequency
- Once daily
- Estimated price
- $50–120
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $22–40
- Website
- https://www.greyhound.com/
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 4 times a day
- Estimated price
- $150–200
- Website
- https://www.keysshuttle.com
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from Buffalo, NY to Rochester, NY
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $20–55
- Website
- https://www.ourbus.com
- Phone
- 905-374-8111
- airsales@niagaraairbus.com
- Website
- niagaraairbus.com
Shuttle from Buffalo Airport to Pearson International Airport Terminal 1
- Ave. Duration
- 2h
- Frequency
- On demand
- Estimated price
- $90–120
- Website
- https://www.niagaraairbus.com
- Schedules at
- https://www.niagaraairbus.com
- Book at
- https://www.niagaraairbus.com
- Phone
- +1 814-574-1827
- Website
- fullingtontours.com
Bus from Buffalo to Pittsburgh
- Ave. Duration
- 7h 30m
- Frequency
- Once daily
- Estimated price
- $110–150
- Website
- https://www.fullingtontours.com
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Buffalo to Pittsburgh
- Ave. Duration
- 7h 30m
- Frequency
- Once daily
- Estimated price
- $40–180
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $40–170
- Flexible
- $80–180
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide














