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How to get fromBuffalo to Florida Keysby plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Find Transport to Florida Keys

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There are 9 ways to get from Buffalo to Florida Keys by plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Key West International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW)plane plane BUF - EYW
    9h 26m
    $174–546

  2. Bus

    1. Take the bus from Buffalo, NY to Youngstown, OHbus bus
    2. Take the bus from Youngstown Bus Stop to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    39h 55m
    $243–423

  3. Bus, train via Newark

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    43h 14m
    $450–962

  4. Drive  1,521.1 mi

    1. Drive from Buffalo to Florida Keyscar car 1,521.1 mi
    26h 10m
    $278–401

  5. Fly Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Buffalo Niagara International Airport (BUF) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane BUF - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 31m
    $294–806

  6. Bus to Rochester, fly to Key West International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Key West International Airport (EYW)plane plane ROC - EYW
    10h 54m
    $226–736

  7. Bus to Toronto Pearson International Airport, fly to Key West International Airport

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Key West International Airport (EYW)plane plane YYZ - EYW
    13h 7m
    $182–523

  8. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    44h 4m
    $514–1,114

  9. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 3h
    $491–1,176

Buffalo to Florida Keys by bus and foot

Calendar4Weekly Services
Duration39h 55mAverage Duration
Ticket$243Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Florida Keys.ExpandLaunch map view
  • Distance: 1,315.1 mi
  • Duration: 9h 26m

What companies run services between Buffalo, NY, USA and Florida Keys, FL, USA?

Delta, American Airlines, and three other airlines fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Buffalo, NY to Florida Keys via Youngstown, OH, Youngstown Bus Stop, Washington Union Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 39h 55m.

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