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How to get fromBuffalo to Florida Keysby plane, bus, train, car, shuttle or ferry

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There are 8 ways to get from Buffalo to Florida Keys by plane, bus, train, car, shuttle, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Key West International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW)plane plane BUF - EYW
    9h 12m
    $313–1,322

  2. Fly Niagara Falls International Airport to Key West International Airport

    cheapest
    1. Fly from Niagara Falls International Airport (IAG) to Key West International Airport (EYW)plane plane IAG - EYW
    24h 22m
    $211–748

  3. Bus, train via Newark

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    43h 4m
    $405–943

  4. Drive 1,521.1 mi

    1. Drive from Buffalo to Florida Keyscar car 1,521.1 mi
    26h 9m
    $278–401

  5. Fly Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Buffalo Niagara International Airport (BUF) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane BUF - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 20m
    $298–882

  6. Fly Buffalo Niagara International Airport to Ft. Myers, ferry

    1. Fly from Buffalo Niagara International Airport (BUF) to Ft. Myers (RSW)plane plane BUF - RSW
    2. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    12h 46m
    $353–1,194

  7. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    44h 9m
    $456–1,048

  8. Bus, train

    1. Take the bus from Buffalo to Pittsburghbus bus
    2. Take the train from Pittsburgh Amtrak Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 3h
    $441–1,098

Buffalo to Florida Keys by bus, train, taxi, and foot

Calendar7Weekly Services
Duration43h 4mAverage Duration
Ticket$405Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and Florida Keys, FL, USA?

American Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW) 4 times a day.

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