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How to get fromDes Moines to Florida Keysby plane, bus, train, car or shuttle

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There are 8 ways to get from Des Moines to Florida Keys by plane, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Des Moines (DSM) to Key West International Airport (EYW)plane plane DSM - EYW
    8h 1m
    $315–1,215

  2. Drive 1,663.9 mi

    cheapest
    1. Drive from Des Moines to Florida Keyscar car 1,663.9 mi
    29h 56m
    $304–439

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 13h
    $600–1,374

  4. Bus, train via Newark

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Newark Penn Stationbus bus
    3. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 15h
    $560–1,174

  5. Fly to Miami International Airport, shuttle

    1. Fly from Des Moines (DSM) to Miami International Airport (MIA)plane plane DSM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 3m
    $320–1,005

  6. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DSM - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 18m
    $310–825

  7. Bus, train, shuttle

    1. Take the bus from Des Moines to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    4. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    2d 18h
    $800–1,747

  8. Bus, train via Warrensburg

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to Warrensburg Chamber Of Commercebus bus
    3. Take the train from Warrensburg Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 22h
    $689–1,654

Des Moines to Florida Keys by bus, foot, train, and taxi

Calendar7Weekly Services
Duration2d 13hAverage Duration
Ticket$600Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Des Moines (DSM) to Key West International Airport (EYW) 4 times a day.

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