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How to get fromDes Moines to Florida Keysby plane, bus, train, car or shuttle

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There are 7 ways to get from Des Moines to Florida Keys by plane, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Des Moines (DSM) to Key West International Airport (EYW)plane plane DSM - EYW
    8h 37m
    $305–1,290

  2. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    cheapest
    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DSM - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 31m
    $290–875

  3. Bus, train via Toledo

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Toledo Bus Stopbus bus
    3. Take the train from Toledo to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 14h
    $372–783

  4. Drive 1,663.9 mi

    1. Drive from Des Moines to Florida Keyscar car 1,663.9 mi
    29h 56m
    $304–439

  5. Fly to Miami International Airport, shuttle

    1. Fly from Des Moines (DSM) to Miami International Airport (MIA)plane plane DSM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 13m
    $320–1,055

  6. Bus, train, shuttle

    1. Take the bus from Des Moines to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    4. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    2d 18h
    $408–1,121

  7. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to Warrensburg Chamber Of Commercebus bus
    3. Take the train from Warrensburg Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 22h
    $326–981

Des Moines to Florida Keys by bus, train, taxi, and foot

Calendar7Weekly Services
Duration2d 14hAverage Duration
Ticket$372Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Des Moines (DSM) to Key West International Airport (EYW) 4 times a day.

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