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How to get fromMobile to Florida Keysby plane, bus (Greyhound), car, train, bus, shuttle, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Mobile to Florida Keys by plane, bus (Greyhound), car, train, bus, shuttle, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mobile Regional Airport to Key West International Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Key West International Airport (EYW)plane plane MOB - EYW
    11h 6m
    $147–427

  2. Bus to Pensacola International Airport, fly to Key West International Airport

    cheapest
    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane plane PNS - EYW
    10h 28m
    $136–381

  3. Bus

    1. Take the bus from Mobile to Miamibus bus Houston
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    21h 54m
    $160–213

  4. Drive 843.3 mi

    1. Drive from Mobile to Florida Keyscar car 843.3 mi
    15h 6m
    $154–223

  5. Train to Gulfport-Biloxi Regional Airport, fly to Key West International Airport

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW)plane plane GPT - EYW
    10h 18m
    $210–628

  6. Bus to Destin–Fort Walton Beach Airport, fly to Key West International Airport

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    9h 57m
    $226–510

  7. Bus to Destin–Fort Walton Beach Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 26m
    $301–610

  8. Bus to Pensacola International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 59m
    $351–561

  9. Bus via Tallahassee

    1. Take the bus from Mobile Bus Station to Tallahasseebus bus
    2. Take the bus from Tallahassee to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h 2m
    $141–272

Mobile to Florida Keys by bus and foot

Calendar12Weekly Services
Duration28h 2mAverage Duration
Ticket$141Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Florida Keys.ExpandLaunch map view
  • Distance: 624 mi
  • Duration: 11h 6m

What companies run services between Mobile, AL, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Mobile Regional Airport (MOB) to Key West International Airport (EYW) 3 times a day. Alternatively, you can take a bus from Mobile to Florida Keys via Miami, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 21h 54m.

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