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How to get fromIrvine to St. Louisby plane, train, bus, train (Amtrak), or car

Find Transport to St. Louis

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There are 6 ways to get from Irvine to St. Louis by plane, train, bus, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL)plane plane SNA - STL
    5h 53m
    $185–553

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Lambert–St. Louis International Airport (STL)plane plane LAX - STL
    7h 4m
    $149–368

  3. Train, bus

    1. Take the train from Tustin to L.A. Union Stationtrain train OC Line
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    42h 15m
    $299–482

  4. Train via Kansas City (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Kansas Citytrain train Southwest Chief
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    42h 34m
    $527–1,169

  5. Drive  1,808 mi

    1. Drive from Irvine to St. Louiscar car 1,808 mi
    28h 48m
    $330–477

  6. Train (Amtrak)

    1. Take the train from Pomona Amtrak to St. Louistrain train Texas Eagle
    2d 11h
    $603–1,408

Irvine to St. Louis by train and bus

Calendar7Weekly Services
Duration42h 15mAverage Duration
Ticket$299Cheapest Price
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Comparing Your Travel Options

Map of how to get from Irvine to St. Louis.ExpandLaunch map view
  • Distance: 1,579.7 mi
  • Duration: 5h 53m

What companies run services between Irvine, CA, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines, and three other airlines fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Tustin to St. Louis via Fullerton, Fullerton Amtrak Station, and Kansas City in around 42h 34m.

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Want to know more about travelling around United States

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