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How to get fromIrvine to St. Louisby plane, train, bus, train (Amtrak), or car

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There are 10 ways to get from Irvine to St. Louis by plane, train, bus, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL)plane plane SNA - STL
    7h 14m
    $175–805

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Lambert–St. Louis International Airport (STL)plane plane LAX - STL
    7h 6m
    $139–578

  3. Train, bus

    1. Take the train from Tustin to L.A. Union Stationtrain train OC Line
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    42h 10m
    $339–512

  4. Train via Kansas City (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Kansas Citytrain train Southwest Chief
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    42h 34m
    $1,107–1,749

  5. Drive  1,808 mi

    1. Drive from Irvine to St. Louiscar car 1,808 mi
    28h 48m
    $299–432

  6. Train to San Diego International Airport, fly

    1. Take the train from Irvine to San Diego Old Town Transportation Centertrain train
    2. Fly from San Diego International Airport (SAN) to Lambert–St. Louis International Airport (STL)plane plane SAN - STL
    8h 22m
    $179–681

  7. Fly from Long Beach Airport

    1. Fly from Long Beach Airport (LGB) to Lambert–St. Louis International Airport (STL)plane plane LGB - STL
    9h 46m
    $283–1,317

  8. Train to Ontario International Airport, fly

    1. Take the train from Tustin to Riverside - Downtowntrain train
    2. Fly from Ontario International Airport (ONT) to Lambert–St. Louis International Airport (STL)plane plane ONT - STL
    9h 49m
    $184–817

  9. Train to Mcclellan–Palomar Airport, fly

    1. Take the train from Tustin to Oceansidetrain train
    2. Fly from Mcclellan–Palomar Airport (CLD) to Lambert–St. Louis International Airport (STL)plane plane CLD - STL
    10h 12m
    $196–875

  10. Train (Amtrak)

    1. Take the train from Pomona Amtrak to St. Louistrain train Texas Eagle
    2d 11h
    $1,303–2,108

Irvine to St. Louis by train and bus

Calendar7Weekly Services
Duration42h 10mAverage Duration
Ticket$339Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Irvine to St. Louis.ExpandLaunch map view
  • Distance: 1,582.3 mi
  • Duration: 7h 14m

What companies run services between Irvine, CA, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Tustin to St. Louis via Fullerton, Fullerton Amtrak Station, and Kansas City in around 42h 34m.

Airlines
Train operators
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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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