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How to get fromIrvine to St. Louisby plane, train, bus, train (Amtrak) or car

Find Transport to St. Louis

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There are 7 ways to get from Irvine to St. Louis by plane, train, bus, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL)plane plane SNA - STL
    5h 48m
    $194–841

  2. Train, bus

    cheapest
    1. Take the train from Tustin to L.A. Union Stationtrain train OC Line
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus Greyhound US1210
    42h 15m
    $138–371

  3. Train via Kansas City (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Kansas Citytrain train Southwest Chief
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    42h 34m
    $190–1,467

  4. Drive 1,808 mi

    1. Drive from Irvine to St. Louiscar car 1,808 mi
    28h 48m
    $330–477

  5. Train to Los Angeles International Airport, fly

    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Lambert–St. Louis International Airport (STL)plane plane LAX - STL
    6h 53m
    $232–778

  6. Train to Burbank Bob Hope Airport, fly

    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Burbank Bob Hope Airport (BUR) to Lambert–St. Louis International Airport (STL)plane plane BUR - STL
    7h 40m
    $396–821

  7. Train (Amtrak)

    1. Take the train from Pomona Amtrak to St. Louistrain train Texas Eagle
    2d 11h
    $203–658

Irvine to St. Louis by train and bus

Calendar12Weekly Services
Duration42h 15mAverage Duration
Ticket$138Cheapest Price
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Questions & Answers

What companies run services between Irvine, CA, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines, and three other airlines fly from John Wayne Airport Orange County (SNA) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a train from Tustin to St. Louis via Fullerton, Fullerton Amtrak Station, and Kansas City in around 42h 34m.

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