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How to get fromAppleton to St. Louisby plane, bus, train, bus (Flixbus), or car

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There are 7 ways to get from Appleton to St. Louis by plane, bus, train, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Appleton International Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL)plane plane ATW - STL
    4h 39m
    $97–490

  2. Bus (Flixbus)

    cheapest
    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus FlixBus 2550
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    11h 25m
    $81–136

  3. Bus, train

    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus FlixBus 2550
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 25m
    $116–241

  4. Drive 443.4 mi

    1. Drive from Appleton to St. Louiscar car 443.4 mi
    7h 33m
    $81–117

  5. Fly Green Bay to Lambert–St. Louis International Airport

    1. Fly from Green Bay (GRB) to Lambert–St. Louis International Airport (STL)plane plane GRB - STL
    6h 6m
    $119–515

  6. Bus to General Mitchell International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Appleton Transit Center to Milwaukee Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 33m
    $507–880

  7. Fly Appleton International Airport to Abraham Lincoln Capital Airport, train

    1. Fly from Appleton International Airport (ATW) to Abraham Lincoln Capital Airport (SPI)plane plane ATW - SPI
    2. Take the train from Springfield to St. Louistrain train
    8h 1m
    $107–408

Appleton to St. Louis by bus, foot, and train

Calendar10Weekly Services
Duration10h 25mAverage Duration
Ticket$116Cheapest Price
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Comparing Your Travel Options

Map of how to get from Appleton to St. Louis.ExpandLaunch map view
  • Distance: 411.9 mi
  • Duration: 4h 39m

What companies run services between Appleton, WI, USA and St. Louis, MO, USA?

Delta, United Airlines, and American Airlines fly from Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Appleton Transit Center to St Louis Bus Station via Chicago Bus Station in around 11h 25m.

Airlines
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