Rome2Rio

How to get fromAppleton to St. Louisby plane, bus, train, bus (Flixbus) or car

Find Transport to St. Louis

See all options

There are 7 ways to get from Appleton to St. Louis by plane, bus, train, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Appleton International Airport

    best
    1. Fly from Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL)plane plane ATW - STL
    4h 34m
    $121–675

  2. Bus (Flixbus)

    cheapest
    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus FlixBus 2550
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus N2521 / ...
    11h 40m
    $58–103

  3. Bus, train

    1. Take the bus from Appleton Transit Center to Chicago Bus Stationbus bus FlixBus 2550
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 25m
    $83–188

  4. Drive 443.4 mi

    1. Drive from Appleton to St. Louiscar car 443.4 mi
    7h 33m
    $81–117

  5. Fly from Green Bay

    1. Fly from Green Bay (GRB) to Lambert–St. Louis International Airport (STL)plane plane GRB - STL
    6h
    $139–695

  6. Bus to General Mitchell International Airport, fly

    1. Take the bus from Appleton Amtrak Station to Milwaukee Airport Amtrak Bus Stopbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 55m
    $166–1,157

  7. Bus, train via Milwaukee

    1. Take the bus from Appleton Amtrak Station to Milwaukeebus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    10h 38m
    $91–245

Appleton to St. Louis by bus, foot, and train

Calendar5Weekly Services
Duration10h 25mAverage Duration
Ticket$83Cheapest Price
See schedules

Questions & Answers

What companies run services between Appleton, WI, USA and St. Louis, MO, USA?

United Airlines, American Airlines, and Delta fly from Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Appleton Transit Center to St Louis Bus Station via Chicago Bus Station in around 11h 40m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

More Questions & Answers

Trips from Appleton

Trips to St. Louis

Popular routes