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How to get fromFlorida to St. Louisby plane, bus (Flixbus, Greyhound), car, or train

Find Transport to St. Louis

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There are 9 ways to get from Florida to St. Louis by plane, bus (Flixbus, Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Jacksonville to Lambert–St. Louis International Airport

    best
    1. Fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL)plane plane JAX - STL
    4h 49m
    $185–956

  2. Bus

    cheapest
    1. Take the bus from Jacksonville to Atlanta Bus Stationbus bus FlixBus 2434 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    19h 10m
    $127–267

  3. Drive 861.3 mi

    1. Drive from Jacksonville to St. Louiscar car 861.3 mi
    15h 15m
    $158–227

  4. Fly Orlando to Lambert–St. Louis International Airport

    1. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    4h 47m
    $135–705

  5. Fly Tampa to Lambert–St. Louis International Airport

    1. Fly from Tampa (TPA) to Lambert–St. Louis International Airport (STL)plane plane TPA - STL
    4h 51m
    $165–805

  6. Fly Orlando Sanford to Midamerica St. Louis Airport, train

    1. Fly from Orlando Sanford (SFB) to Midamerica St. Louis Airport (BLV)plane plane SFB - BLV
    2. Take the train from SHILOH-SCOTT station to CIVIC CENTER stationtrain train
    3h 58m
    $167–515

  7. Fly Fort Lauderdale–Hollywood International Airport to Lambert–St. Louis International Airport

    1. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Lambert–St. Louis International Airport (STL)plane plane FLL - STL
    4h 57m
    $175–806

  8. Fly Miami International Airport to Lambert–St. Louis International Airport

    1. Fly from Miami International Airport (MIA) to Lambert–St. Louis International Airport (STL)plane plane MIA - STL
    4h 54m
    $156–756

  9. Fly Ft. Myers to Lambert–St. Louis International Airport

    1. Fly from Ft. Myers (RSW) to Lambert–St. Louis International Airport (STL)plane plane RSW - STL
    6h 5m
    $206–958

Florida to St. Louis by bus

Calendar12Weekly Buses
Duration19h 10mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

Map of how to get from Florida to St. Louis.ExpandLaunch map view
  • Distance: 783.5 mi
  • Duration: 4h 49m

What companies run services between Florida, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Jacksonville to St Louis Bus Station via Atlanta Bus Station in around 19h 10m.

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