Rome2Rio

How to get fromFlorida to St. Louisby plane, bus (Flixbus, Greyhound), car, train, or bus (Greyhound)

Find Transport to St. Louis

See all options

There are 10 ways to get from Florida to St. Louis by plane, bus (Flixbus, Greyhound), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Jacksonville to Lambert–St. Louis International Airport

    best
    1. Fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL)plane plane JAX - STL
    4h 49m
    $175–956

  2. Bus

    cheapest
    1. Take the bus from Jacksonville to Atlanta Bus Stationbus bus FlixBus 2434 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    18h 16m
    $121–302

  3. Drive 861.3 mi

    1. Drive from Jacksonville to St. Louiscar car 861.3 mi
    15h 15m
    $158–227

  4. Fly Orlando to Lambert–St. Louis International Airport

    1. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    4h 52m
    $265–855

  5. Fly Tampa to Lambert–St. Louis International Airport

    1. Fly from Tampa (TPA) to Lambert–St. Louis International Airport (STL)plane plane TPA - STL
    4h 51m
    $135–705

  6. Fly Fort Lauderdale–Hollywood International Airport to Lambert–St. Louis International Airport

    1. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Lambert–St. Louis International Airport (STL)plane plane FLL - STL
    4h 52m
    $255–606

  7. Fly Orlando Sanford to Midamerica St. Louis Airport, train

    1. Fly from Orlando Sanford (SFB) to Midamerica St. Louis Airport (BLV)plane plane SFB - BLV
    2. Take the train from SHILOH-SCOTT station to CIVIC CENTER stationtrain train
    4h 1m
    $167–535

  8. Fly Miami International Airport to Lambert–St. Louis International Airport

    1. Fly from Miami International Airport (MIA) to Lambert–St. Louis International Airport (STL)plane plane MIA - STL
    4h 54m
    $146–706

  9. Fly Ft. Myers to Lambert–St. Louis International Airport

    1. Fly from Ft. Myers (RSW) to Lambert–St. Louis International Airport (STL)plane plane RSW - STL
    6h 5m
    $186–908

  10. Bus via Clarksville Park & Ride (Greyhound)

    1. Take the bus from Jacksonville to Tallahasseebus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Clarksville Park & Ridebus bus
    4. Take the bus from Clarksville Park & Ride to St Louis Bus Stationbus bus
    23h 58m
    $160–321

Florida to St. Louis by bus

Calendar14Weekly Buses
Duration18h 16mAverage Duration
Ticket$121Cheapest Price
See schedules

Questions & Answers

What companies run services between Florida, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Jacksonville to St Louis Bus Station via Atlanta Bus Station in around 18h 16m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Florida

Trips to St. Louis

Popular routes