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How to get fromFlorida to St. Louisby plane, bus (Flixbus, Greyhound), or car

Find Transport to St. Louis

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There are 8 ways to get from Florida to St. Louis by plane, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Jacksonville

    best
    1. Fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL)plane plane JAX - STL
    4h 48m
    $100–556

  2. Bus

    1. Take the bus from Jacksonville to Atlanta Bus Stationbus bus FlixBus 2434 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    19h 20m
    $137–247

  3. Drive  861.3 mi

    1. Drive from Jacksonville to St. Louiscar car 861.3 mi
    15h 15m
    $158–227

  4. Fly from Orlando

    1. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    4h 52m
    $185–325

  5. Fly from Tampa

    1. Fly from Tampa (TPA) to Lambert–St. Louis International Airport (STL)plane plane TPA - STL
    4h 49m
    $555–2,005

  6. Fly from Fort Lauderdale–Hollywood International Airport

    1. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Lambert–St. Louis International Airport (STL)plane plane FLL - STL
    4h 57m
    $505–1,106

  7. Fly from Miami International Airport

    1. Fly from Miami International Airport (MIA) to Lambert–St. Louis International Airport (STL)plane plane MIA - STL
    4h 54m
    $506–956

  8. Fly from Ft. Myers

    1. Fly from Ft. Myers (RSW) to Lambert–St. Louis International Airport (STL)plane plane RSW - STL
    6h 10m
    $136–708

Florida to St. Louis by bus

Calendar12Weekly Buses
Duration19h 20mAverage Duration
Ticket$137Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florida to St. Louis.ExpandLaunch map view
  • Distance: 783.5 mi
  • Duration: 4h 48m

What companies run services between Florida, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Jacksonville to St Louis Bus Station via Atlanta Bus Station in around 19h 20m.

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