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How to get fromDes Moines to Key Westby plane, bus, train, shuttle, or car

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There are 5 ways to get from Des Moines to Key West by plane, bus, train, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Key West International Airport (EYW)plane plane DSM - EYW
    5h 46m
    $169–684

  2. Bus, train, shuttle

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    2d 12h
    $897–1,726

  3. Bus, train via Newark

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Newark Penn Stationbus bus
    3. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 17h
    $661–1,307

  4. Drive 1,668.2 mi

    1. Drive from Des Moines to Key Westcar car 1,668.2 mi
    30h 46m
    $305–440

  5. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 14h
    $772–1,636

Des Moines to Key West by bus, foot, train, taxi, and shuttle

Calendar7Weekly Services
Duration2d 12hAverage Duration
Ticket$897Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Key West.ExpandLaunch map view
  • Distance: 1,366.2 mi
  • Duration: 5h 46m

What companies run services between Des Moines, IA, USA and Key West, FL, USA?

Delta, American Airlines, and United Airlines fly from Des Moines (DSM) to Key West International Airport (EYW) every 4 hours.

Airlines
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