There are 5 ways to get from Des Moines to Key West by plane, bus, train, shuttle, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Des Moines (DSM) to Key West International Airport (EYW)plane DSM - EYW
5h 51m$259–1,134Bus, train, shuttle
- Take the bus from Des Moines to Chicago Bus Stationbus
- Take the train from Chicago Union Station to Miami Amtrak Stationtrain
- Take a shuttle bus from Miami, FL - International Airport to Key West, FL
2d 12h$393–982Bus, train via Newark
- Take the bus from Des Moines to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Newark Penn Stationbus
- Take the train from Newark Penn Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
2d 15h$362–1,118Drive 1,679.3 mi
- Drive from Des Moines to Key Westcar 1,679.3 mi
30h 19m$307–443Bus, train
- Take the bus from Des Moines to St. Paulbus
- Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
2d 19h$302–1,037
Des Moines to Key West by bus, train, taxi, and foot
Questions & Answers
The cheapest way to get from Des Moines to Key West is to drive which costs $300 - $450 and takes 30h 19m.
The fastest way to get from Des Moines to Key West is to fly which takes 5h 51m and costs $250 - $1,200.
The distance between Des Moines and Key West is 1374 miles. The road distance is 1689.1 miles.
The best way to get from Des Moines to Key West without a car is to bus and train and shuttle which takes 2 days 12h and costs $390 - $1,000.
It takes approximately 5h 51m to get from Des Moines to Key West, including transfers.
Key West is 1h ahead of Des Moines. It is currently 6:53 AM in Des Moines and 7:53 AM in Key West.
Yes, the driving distance between Des Moines to Key West is 1689 miles. It takes approximately 30h 19m to drive from Des Moines to Key West.
There are 797+ hotels available in Key West.
What companies run services between Des Moines, IA, USA and Key West, FL, USA?
American Airlines and Delta fly from Des Moines (DSM) to Key West International Airport (EYW) 4 times a day.
- Website
- aa.com
Flights from Des Moines to Key West International Airport via Miami
- Ave. Duration
- 5h 33m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,100
Flights from Des Moines to Key West International Airport via Charlotte
- Ave. Duration
- 6h 14m
- When
- Every day
- Estimated price
- $250–1,200
- Website
- delta.com
Flights from Des Moines to Key West International Airport via Atlanta
- Ave. Duration
- 6h 25m
- When
- Every day
- Estimated price
- $230–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Miami Amtrak Station
- Ave. Duration
- 46h 29m
- Frequency
- Once daily
- Estimated price
- $170–650
- Website
- https://www.amtrak.com/home.html
Train from Newark Penn Station to Miami Amtrak Station
- Ave. Duration
- 28h 6m
- Frequency
- Once daily
- Estimated price
- $170–700
- Website
- https://www.amtrak.com/home.html
Train from St. Paul-Minneapolis to Chicago Union Station
- Ave. Duration
- 7h 24m
- Frequency
- 3 times a day
- Estimated price
- $60–210
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 3 times a day
- Estimated price
- $40–95
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $22–40
- Website
- https://www.greyhound.com/
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Miami, FL - International Airport to Key West, FL
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $150–200
- Website
- https://www.keysshuttle.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to Newark Penn Station
- Ave. Duration
- 19h 25m
- Frequency
- Once daily
- Estimated price
- $100–250
- Schedules at
- flixbus.com
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to St. Paul
- Ave. Duration
- 4h 50m
- Frequency
- Once daily
- Estimated price
- $23–110
- Book at
- https://www.jeffersonlines.com
Want to know more about travelling around United States
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