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How to get fromDes Moines to Key WestBy plane, bus, train, shuttle, or car

Find Transport to Key West

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There are 5 ways to get from Des Moines to Key West by plane, bus, train, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Key West International Airport (EYW)plane plane DSM - EYW
    5h 56m
    $199–834

  2. Bus, train, shuttle

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    2d 12h
    $800–1,635

  3. Bus, train via Newark

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to Newark Penn Stationbus bus
    3. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 14h
    $581–1,229

  4. Drive 1,668.2 mi

    1. Drive from Des Moines to Key Westcar car 1,668.2 mi
    30h 46m
    $305–440

  5. Bus, train

    1. Take the bus from Des Moines to Bloomington-Normalbus bus
    2. Take the train from Bloomington-Normal to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 16h
    $668–1,532

Des Moines to Key West by bus, foot, train, and taxi

Calendar7Weekly Services
Duration2d 14hAverage Duration
Ticket$581Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Key West, FL, USA?

American Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Key West International Airport (EYW) every 4 hours.

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