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How to get fromDes Moines to Indianaby plane, bus (Greyhound, Flixbus), car, train or bus

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There are 6 ways to get from Des Moines to Indiana by plane, bus (Greyhound, Flixbus), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to South Bend

    best
    1. Fly from Des Moines (DSM) to South Bend (SBN)plane plane DSM - SBN
    3h 58m
    $142–738

  2. Bus, train

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    13h 8m
    $74–160

  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the bus from Chicago Bus Station to Indianapolisbus bus FlixBus N2640 / ...
    11h 55m
    $79–160

  4. Drive 465.7 mi

    1. Drive from Des Moines to Indianapoliscar car 465.7 mi
    7h 53m
    $85–123

  5. Fly to Chicago O'Hare International Airport, train

    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 46m
    $92–455

  6. Fly to Chicago Midway International Airport, train

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane plane DSM - MDW
    2. Take the train from Van Buren St. to Gary Metro Centertrain train
    3h 25m
    $117–635

Des Moines to Indiana by bus

Calendar19Weekly Buses
Duration11h 55mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Indiana, USA?

United Airlines, Delta, and American Airlines fly from Des Moines (DSM) to South Bend (SBN) every 4 hours. Alternatively, you can take a bus from Des Moines to Indianapolis via Chicago Bus Station in around 11h 55m.

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