There are 5 ways to get from Depew to Chicago by plane, train (Amtrak), bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Chicago Midway International Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane BUF - MDW
2h 25m$109–575Bus (Greyhound)
cheapest- Take the bus from Buffalo to Cleveland Bus Stationbus Greyhound US0171 / ...
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
13h 39m$82–157Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain Lake Shore Limited
11h 38m$172–342Drive 535.3 mi
- Drive from Depew to Chicagocar 535.3 mi
9h 8m$98–142Fly to Chicago O'Hare International Airport
- Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane BUF - ORD
2h 53m$89–435
Depew to Chicago by bus and train (Amtrak)
Questions & Answers
The cheapest way to get from Depew to Chicago is to bus which costs $80 - $160 and takes 13h 39m.
The fastest way to get from Depew to Chicago is to fly which takes 2h 25m and costs $100 - $600.
No, there is no direct bus from Depew to Chicago station. However, there are services departing from Broadway & Meridian Street and arriving at Chicago Bus Station via Buffalo and Cleveland Bus Station. The journey, including transfers, takes approximately 13h 39m.
No, there is no direct train from Depew station to Chicago station. However, there are services departing from Buffalo Depew Station and arriving at Chicago Union Station via . The journey, including transfers, takes approximately 11h 38m.
The distance between Depew and Chicago is 485 miles. The road distance is 538.4 miles.
The best way to get from Depew to Chicago without a car is to train which takes 11h 38m and costs $170 - $350.
It takes approximately 2h 25m to get from Depew to Chicago, including transfers.
Depew to Chicago bus services, operated by Greyhound USA, depart from Buffalo station.
Depew to Chicago train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Depew to Chicago is to fly which takes 2h 25m and costs $100 - $600. Alternatively, you can train, which costs $170 - $350 and takes 11h 38m, you could also bus, which costs $80 - $160 and takes 13h 39m.
What companies run services between Depew, NY, USA and Chicago, IL, USA?
Southwest Airlines and Delta fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $170–340 and the journey takes 10h 33m.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $90–550
- Website
- united.com
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 1m
- When
- Every day
- Estimated price
- $70–410
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $100–550
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 5m
- When
- Every day
- Estimated price
- $70–410
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Reagan Washington
- Ave. Duration
- 4h 36m
- When
- Saturday
- Estimated price
- $100–550
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Philadelphia
- Ave. Duration
- 4h 50m
- When
- Monday to Saturday
- Estimated price
- $110–550
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 44m
- When
- Every day
- Estimated price
- $90–550
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 49m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $70–410
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $170–340
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $30–60
- Website
- https://www.greyhound.com/
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $50–95
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
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More Questions & Answers
Depew to Chicago bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Chicago is 1h behind Depew. It is currently 10:08 PM in Depew and 9:08 PM in Chicago.
Depew to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Depew to Chicago is 538 miles. It takes approximately 9h 8m to drive from Depew to Chicago.
Book your Depew to Chicago train tickets online with Omio.
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