The average train between Rome and Iseo takes 6h 53m and the fastest train takes 4h 59m. The train service runs several times per day from Rome to Iseo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Rome and Iseo. The earliest departure is at 8:25 AM in the morning, and the last departure from Rome is at 7:25 PM which arrives into Iseo at 6:24 AM. All services require a transfer, and take on average 6h 53m. The schedules shown below are for the next available departures.

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10h 59m • 1 change

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4h 59m • 1 change
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10h 59m • 1 change

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11h 59m • 1 change

4h 59m • 1 change

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10h 59m • 1 change

4h 59m • 1 change

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11h 59m • 1 change
Want to know about travelling from Rome to Iseo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Iseo. However, there are services departing from Rome station and arriving at Iseo station via Brescia. The journey, including transfers, takes approximately 6h 53m.
Rome to Iseo train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Iseo train services, operated by ItaloTreno, arrive at Brescia station.
Book your Rome to Iseo train tickets online with ItaloTreno and Trenord.
The distance between Rome and Iseo is 461.8 km. The road distance is 669 km.
ItaloTreno operates a train from Roma Termini to Brescia every 4 hours. Tickets cost €80–170 and the journey takes 4h 6m.