The average train between Pilsen and Mainz takes 8h 23m and the fastest train takes 7h 4m. The train service runs several times per day from Pilsen to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Pilsen and Mainz. The earliest departure is at 7:10 AM in the morning, and the last departure from Pilsen is at 7:10 PM which arrives into Mainz at 12:18 PM. All services require a transfer, and take on average 8h 23m. The schedules shown below are for the next available departures.

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7h 8m • 1 changeWant to know about travelling from Pilsen to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Pilsen to Mainz. However, there are services departing from Plzen Hlavni Nadrazi station and arriving at Mainz Hbf station via Regensburg Hbf station. The journey, including transfers, takes approximately 8h 23m.
Pilsen to Mainz train services, operated by ÖBB EuroCity, depart from Plzen Hlavni Nadrazi station.
Pilsen to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Mainz Hbf station.
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The distance between Pilsen and Mainz is 366.3 km. The road distance is 447 km.
You can take a train from Plzen Hlavni Nadrazi to Mainz Hbf via Regensburg Hbf in around 7h 14m.