The average train between Mannheim and Lyon takes 9h 29m and the fastest train takes 5h 16m. The train service runs several times per day from Mannheim to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Mannheim and Lyon. The earliest departure is at 7:39 AM in the morning, and the last departure from Mannheim is at 5:39 PM which arrives into Lyon at 10:59 AM. All services require a transfer at Strasbourg Bahnhof and take an average of 9h 29m. The schedules shown below are for the next available departures.

5h 20m • 1 change

6h 19m • 1 change
Arrives next day

17h 20m • 1 change

6h 19m • 1 change

5h 16m • 1 change
Arrives next day

17h 20m • 1 change
Want to know about travelling from Mannheim to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Lyon. However, there are services departing from Mannheim station and arriving at Lyon station via Strasbourg Bahnhof. The journey, including transfers, takes approximately 9h 29m.
Mannheim to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Lyon Part Dieu station.
Book your Mannheim to Lyon train tickets online with Deutsche Bahn Intercity (DB IC) and TGV inOui.
The distance between Mannheim and Lyon is 496.5 km. The road distance is 646 km.
You can take a train from Mannheim, Hauptbahnhof to Lyon Part Dieu via Strasbourg Bahnhof and Strasbourg in around 6h 7m.