Mainz to Lyon Trains

Mainz to Lyon trains

Travel from

Search accommodation with Expedia

Trip Overview

The average train between Mainz and Lyon takes 12h 23m and the fastest train takes 7h 32m. The train service runs several times per day from Mainz to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 23m
Duration: 714 km
Distance: €166
Average price: 3 times a day
Frequency

Train

best

Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhoftrain 82 / ...
Take the train from Strasbourg to Lyon Part Dieutrain Tgv

8h 36m

€123–257

Mainz to Lyon train times

Trains run 3 times a day between Mainz and Lyon. The earliest departure is at 5:00 AM in the morning, and the last departure from Mainz is at 9:21 PM which arrives into Lyon at 6:01 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 12h 23m. The schedules shown below are for the next available departures.

Departing Monday, October 26, 2026

5:18 AM → 12:59 PM
7h 41m • 2 changes
8:26 AM → 5:59 PM
9h 33m • 2 changes
4:22 PM → 10:59 AM
Arrives next day
18h 37m • 2 changes

Departing Tuesday, October 27, 2026

5:18 AM → 12:59 PM
7h 41m • 2 changes
8:26 AM → 5:59 PM
9h 33m • 2 changes
4:22 PM → 10:59 AM
Arrives next day
18h 37m • 2 changes

Departing Wednesday, October 28, 2026

5:18 AM → 12:59 PM
7h 41m • 2 changes
8:26 AM → 5:59 PM
9h 33m • 2 changes
4:22 PM → 10:59 AM
Arrives next day
18h 37m • 2 changes

Departing Thursday, October 29, 2026

5:18 AM → 12:59 PM
7h 41m • 2 changes
8:26 AM → 5:59 PM
9h 33m • 2 changes
4:22 PM → 10:59 AM
Arrives next day
18h 37m • 2 changes

Departing Friday, October 30, 2026

5:00 AM → 12:59 PM
7h 59m • 2 changes
9:27 AM → 5:03 PM
7h 36m • 2 changes
12:26 PM → 7:58 PM
7h 32m • 2 changes
4:22 PM → 12:44 PM
Arrives next day
20h 22m • 2 changes
Show more

Departing Saturday, October 31, 2026

9:21 PM → 12:59 PM
Arrives next day
15h 38m • 2 changes

Frequently asked questions

Want to know about travelling from Mainz to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.