The average train between Mainz and Lyon takes 8h 45m and the fastest train takes 7h 16m. The train service runs several times per day from Mainz to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Mainz and Lyon. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz is at 8:42 PM which arrives into Lyon at 10:59 AM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 8h 45m. The schedules shown below are for the next available departures.



7h 17m • 3 changes



7h 16m • 3 changes
Arrives next day



14h 17m • 3 changes



7h 19m • 3 changes



7h 41m • 3 changes



7h 17m • 3 changes



7h 16m • 3 changes



7h 19m • 3 changes



7h 41m • 3 changes



7h 17m • 3 changes



7h 16m • 3 changes



7h 19m • 3 changes



8h 21m • 3 changes



7h 17m • 3 changes



7h 16m • 3 changes



7h 19m • 3 changes



8h 21m • 3 changes



7h 17m • 3 changes



7h 16m • 3 changes



7h 19m • 3 changes



8h 21m • 3 changes



7h 17m • 3 changes



7h 16m • 3 changes
Want to know about travelling from Mainz to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Lyon. However, there are services departing from Mainz station and arriving at Lyon station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 8h 45m.
Mainz to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Lyon Part Dieu station.
Book your Mainz to Lyon train tickets online with Deutsche Bahn Intercity (DB IC), SWEG (Südwestdeutsche Landesverkehrs-GmbH) and 2 other operators.
The distance between Mainz and Lyon is 535.9 km. The road distance is 731 km.
You can take a train from Mainz, Hauptbahnhof to Lyon Part Dieu via Mannheim, Hauptbahnhof, Offenburg Bahnhof, Strasbourg Bahnhof, and Strasbourg in around 8h.