The average train between Mainz and Lyon takes 9h 11m and the fastest train takes 6h 14m. The train service runs several times per day from Mainz to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Mainz and Lyon. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz is at 4:42 PM which arrives into Lyon at 10:56 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 9h 11m. The schedules shown below are for the next available departures.


7h 7m • 2 changes

7h 17m • 2 changes

6h 45m • 2 changesArrives next day


18h 17m • 2 changes

7h 7m • 2 changes

7h 17m • 2 changes

7h 45m • 2 changesArrives next day


18h 17m • 2 changes

7h 7m • 2 changes

6h 21m • 2 changes

6h 45m • 2 changesArrives next day


18h 17m • 2 changes

6h 21m • 2 changes

6h 45m • 2 changesArrives next day


18h 17m • 2 changesWant to know about travelling from Mainz to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Lyon. However, there are services departing from Mainz station and arriving at Lyon station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 9h 11m.
Mainz to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Lyon train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Lyon Part Dieu station.
Book your Mainz to Lyon train tickets online with Deutsche Bahn Intercity (DB IC), TGV inOui and 2 other operators.
The distance between Mainz and Lyon is 535.9 km. The road distance is 710 km.
You can take a train from Mainz, Hauptbahnhof to Lyon Part Dieu via Mannheim, Hauptbahnhof, Strasbourg Bahnhof, and Strasbourg in around 7h 33m.