The average train between Mainz and Leipzig takes 3h 57m and the fastest train takes 3h 55m. There is a train service every few hours from Mainz to Leipzig. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Leipzig. The earliest departure is at 5:05 AM in the morning, and the last departure from Mainz is at 9:14 PM which arrives into Leipzig at 1:39 AM. All services require a transfer, and take on average 3h 57m. The schedules shown below are for the next available departures.

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3h 57m • 1 changeWant to know about travelling from Mainz to Leipzig? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Leipzig. However, there are services departing from Frankfurt station and arriving at Leipzig Hbf station via Leipzig Hbf station. The journey, including transfers, takes approximately 3h 57m.
Mainz to Leipzig train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Mainz to Leipzig train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Leipzig Hbf station.
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The distance between Mainz and Leipzig is 325.4 km. The road distance is 413 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Leipzig Hbf hourly. Tickets cost €60–140 and the journey takes 3h 12m.