The average train between Mainz and Leipzig takes 4h 11m and the fastest train takes 3h 47m. There is a train service every few hours from Mainz to Leipzig. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Leipzig. The earliest departure is at 2:04 AM at night, and the last departure from Mainz is at 10:16 PM which arrives into Leipzig at 7:09 AM. All services require a transfer at Frankfurt and take an average of 4h 11m. The schedules shown below are for the next available departures.


5h 5m • 2 changes

3h 50m • 2 changes

3h 57m • 2 changes

3h 50m • 2 changes

3h 50m • 2 changes

3h 57m • 2 changes

3h 50m • 2 changes

3h 57m • 2 changes

5h 29m • 2 changes

3h 50m • 2 changes

3h 56m • 2 changes

3h 50m • 2 changesWant to know about travelling from Mainz to Leipzig? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Leipzig. However, there are services departing from Mainz station and arriving at Leipzig station via Erfurt Hbf. The journey, including transfers, takes approximately 4h 11m.
Mainz to Leipzig train services, operated by vlexx, depart from Frankfurt station.
Mainz to Leipzig train services, operated by vlexx, arrive at Leipzig Hbf station.
Book your Mainz to Leipzig train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz and Leipzig is 325.4 km. The road distance is 409 km.
You can take a train from Mainz, Römisches Theater to Leipzig Hbf via Frankfurt and Erfurt Hbf in around 4h 18m.