The average train between Mainz and Prague takes 9h 4m and the fastest train takes 8h 7m. The train service runs several times per day from Mainz to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Prague. The earliest departure is at 4:04 AM at night, and the last departure from Mainz is at 9:35 PM which arrives into Prague at 10:21 AM. All services require a transfer at Frankfurt and take an average of 9h 4m. The schedules shown below are for the next available departures.



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8h 7m • 3 changes
Want to know about travelling from Mainz to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Prague. However, there are services departing from Mainz station and arriving at Prague station via Nürnberg Hbf. The journey, including transfers, takes approximately 9h 4m.
Mainz to Prague train services, operated by Deutsche Bahn Regio (DB Regional), depart from Frankfurt station.
Mainz to Prague train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Praha Hlavni Nadrazi station.
Book your Mainz to Prague train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 3 other operators.
The distance between Mainz and Prague is 438.7 km. The road distance is 603 km.
You can take a train from Mainz, Römisches Theater to Praha Hlavni Nadrazi via Frankfurt, Nürnberg Hbf, and Schwandorf in around 9h 35m.