Mainz to Prague Trains

Mainz to Prague trains

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Trip Overview

The average train between Mainz and Prague takes 9h 3m and the fastest train takes 8h 7m. The train service runs several times per day from Mainz to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 3m
Duration: 603 km
Distance: Kč 3,414
Average price: Every 4 hours
Frequency

Train via Nuremberg

best

Take the train from Frankfurt to Nürnberg Hbftrain 41 / ...
Take the train from Nürnberg Hbf to Schwandorftrain
Take the train from Schwandorf to Praha Hlavni Nadrazitrain Re

9h 6m

Kč 2,735–6,585

Mainz to Prague train times

Trains run every 4 hours between Mainz and Prague. The earliest departure is at 4:04 AM at night, and the last departure from Mainz is at 11:14 PM which arrives into Prague at 12:21 PM. All services require a transfer at Frankfurt and take an average of 9h 3m. The schedules shown below are for the next available departures.

Departing Saturday, October 10, 2026

4:05 AM → 12:21 PM
8h 16m • 3 changes
6:14 AM → 2:21 PM
8h 7m • 3 changes
8:14 AM → 4:21 PM
8h 7m • 3 changes
10:14 AM → 6:21 PM
8h 7m • 3 changes
Show more

Departing Sunday, October 11, 2026

6:14 AM → 2:21 PM
8h 7m • 3 changes
8:14 AM → 4:21 PM
8h 7m • 3 changes
10:14 AM → 6:21 PM
8h 7m • 3 changes
12:14 PM → 8:21 PM
8h 7m • 3 changes
Show more

Departing Monday, October 12, 2026

4:04 AM → 12:21 PM
8h 17m • 3 changes
6:14 AM → 2:21 PM
8h 7m • 3 changes
8:14 AM → 4:21 PM
8h 7m • 3 changes
10:14 AM → 6:21 PM
8h 7m • 3 changes
Show more

Departing Tuesday, October 13, 2026

4:04 AM → 12:21 PM
8h 17m • 3 changes
6:14 AM → 2:21 PM
8h 7m • 3 changes
8:14 AM → 4:21 PM
8h 7m • 3 changes
10:14 AM → 6:21 PM
8h 7m • 3 changes
Show more

Departing Wednesday, October 14, 2026

4:04 AM → 12:21 PM
8h 17m • 3 changes
6:14 AM → 2:21 PM
8h 7m • 3 changes
8:14 AM → 4:21 PM
8h 7m • 3 changes
10:14 AM → 6:21 PM
8h 7m • 3 changes
Show more

Departing Thursday, October 15, 2026

4:04 AM → 12:21 PM
8h 17m • 3 changes
6:14 AM → 2:21 PM
8h 7m • 3 changes
8:14 AM → 4:21 PM
8h 7m • 3 changes
10:14 AM → 6:21 PM
8h 7m • 3 changes
Show more

Frequently asked questions

Want to know about travelling from Mainz to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Trip Overview

Train via Nuremberg

Mainz to Prague train times

Departing Saturday, October 10, 2026

4:05 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Departing Sunday, October 11, 2026

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

12:14 PM → 8:21 PM

Departing Monday, October 12, 2026

4:04 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Departing Tuesday, October 13, 2026

4:04 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Departing Wednesday, October 14, 2026

4:04 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Departing Thursday, October 15, 2026

4:04 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Frequently asked questions

What companies run services between Mainz, Germany and Prague, Czechia?

Train from Frankfurt to Nürnberg Hbf

Mainz to Prague trains

Find Transport to Prague

Trip Overview

Train via Nuremberg

Mainz to Prague train times

Departing Saturday, October 10, 2026

4:05 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Departing Sunday, October 11, 2026

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

12:14 PM → 8:21 PM

Departing Monday, October 12, 2026

4:04 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Departing Tuesday, October 13, 2026

4:04 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Departing Wednesday, October 14, 2026

4:04 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Departing Thursday, October 15, 2026

4:04 AM → 12:21 PM

6:14 AM → 2:21 PM

8:14 AM → 4:21 PM

10:14 AM → 6:21 PM

Frequently asked questions

What companies run services between Mainz, Germany and Prague, Czechia?

Train from Frankfurt to Nürnberg Hbf

Where to next?

Train trips from Mainz

Train trips to Prague

Alternative transport options