The average train between Prague and Brussels takes 15h 35m and the fastest train takes 12h 45m. The train service runs several times per day from Prague to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Prague and Brussels. The earliest departure is at 6:41 AM in the morning, and the last departure from Prague is at 6:41 PM which arrives into Brussels at 3:26 PM. All services require a transfer at Dresden Bahnhof Neustadt and take an average of 15h 35m. The schedules shown below are for the next available departures.


12h 45m • 2 changes


12h 45m • 2 changes


12h 45m • 2 changes
Arrives next day


18h 45m • 2 changes


12h 45m • 2 changes


12h 45m • 2 changes


12h 45m • 2 changes
Arrives next day


18h 45m • 2 changes


12h 45m • 2 changes


12h 45m • 2 changes


12h 45m • 2 changes
Arrives next day


18h 45m • 2 changes


12h 45m • 2 changes


12h 45m • 2 changes


12h 45m • 2 changes
Arrives next day


18h 45m • 2 changes
Want to know about travelling from Prague to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Brussels. However, there are services departing from Prague station and arriving at Brussels station via Dresden-Neustadt. The journey, including transfers, takes approximately 15h 35m.
Prague to Brussels train services, operated by ÖBB EuroCity, depart from Praha-Holesovice station.
Prague to Brussels train services, operated by ÖBB EuroCity, arrive at Brussels-Nord station.
Book your Prague to Brussels train tickets online with ÖBB EuroCity, Deutsche Bahn Intercity (DB IC) and 3 other operators.
The distance between Prague and Brussels is 717.3 km. The road distance is 1,070 km.
You can take a train from Praha-Holesovice to Brussels-Nord via Dresden Bahnhof Neustadt and Frankfurt in around 11h 29m.