The average train between Prague and Brussels takes 13h 51m and the fastest train takes 11h 51m. The train service runs several times per day from Prague to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Prague and Brussels. The earliest departure is at 5:35 AM in the morning, and the last departure from Prague is at 5:35 PM which arrives into Brussels at 11:26 AM. All services require a transfer at Schwandorf and take an average of 13h 51m. The schedules shown below are for the next available departures.



11h 51m • 3 changes


11h 51m • 3 changes


11h 51m • 3 changes


11h 51m • 3 changesWant to know about travelling from Prague to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Brussels. However, there are services departing from Praha Hlavni Nadrazi station and arriving at Brussels-Nord station via Schwandorf station, Nürnberg Hbf station and Frankfurt station. The journey, including transfers, takes approximately 13h 51m.
Prague to Brussels train services, operated by ÖBB EuroCity, depart from Praha Hlavni Nadrazi station.
Prague to Brussels train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Brussels-Nord station.
Book your Prague to Brussels train tickets online with Omio.
The distance between Prague and Brussels is 717.3 km. The road distance is 865 km.
You can take a train from Praha Hlavni Nadrazi to Brussels-Nord via Schwandorf, Nürnberg Hbf, and Frankfurt in around 12h 9m.