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There are 7 ways to get from Mainz to Prague by plane, subway, bus, train, night train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Prague, subway  •  3h 54m

  1. Fly from Frankfurt (FRA) to Prague (PRG) FRA - PRG
  2. Take the subway from Nádraží Veleslavín to Staroměstská

Cheapest option

Bus  •  7h 55m

  1. Take the bus from Frankfurt Main Train Station to Prague Wilsonova Bus Station RegioJet 540

5 alternative options

Fly to Dresden, bus  •  5h 12m

  1. Fly from Frankfurt (FRA) to Dresden (DRS) FRA - DRS
  2. Take the bus from Dresden Hauptbahnhof to Prague

Train via Nuremberg  •  9h 35m

  1. Take the train from Frankfurt(Main)Hbf to Nürnberg Hbf 41 / ...
  2. Take the train from Nürnberg Hbf to Schwandorf
  3. Take the train from Schwandorf to Praha Hlavni Nadrazi Re

Train  •  10h 24m

  1. Take the train from Frankfurt(Main)Hbf to Praha Hlavni Nadrazi Ec

Night train  •  10h 19m

  1. Take the night train from Frankfurt(Main)Hbf to Praha Hlavni Nadrazi En

Drive  •  4h 37m

  1. Drive from Mainz to Prague 542 km

Questions & Answers

The cheapest way to get from Mainz to Prague is to bus which costs €20 - €28 and takes 7h 55m.

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The fastest way to get from Mainz to Prague is to fly and subway which takes 3h 54m and costs €85 - €310.

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No, there is no direct bus from Mainz station to Prague station. However, there are services departing from Mainz central train station and arriving at Prague Wilsonova Bus Station via Frankfurt Main Train Station. The journey, including transfers, takes approximately 7h 55m.

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No, there is no direct train from Mainz to Prague. However, there are services departing from Mainz, Römisches Theater and arriving at Praha Hlavni Nadrazi via Frankfurt(Main)Hbf, Nürnberg Hbf and Schwandorf. The journey, including transfers, takes approximately 9h 35m.

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The distance between Mainz and Prague is 439 km. The road distance is 542 km.

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The best way to get from Mainz to Prague without a car is to bus which takes 7h 55m and costs €20 - €28.

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It takes approximately 3h 54m to get from Mainz to Prague, including transfers.

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Mainz to Prague bus services, operated by RegioJet, depart from Frankfurt Main Train Station.

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Mainz to Prague train services, operated by Deutsche Bahn Intercity-Express, depart from Frankfurt(Main)Hbf station.

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The best way to get from Mainz to Prague is to bus which takes 7h 55m and costs €20 - €28. Alternatively, you can train via Nuremberg, which costs and takes 9h 35m.

Mode details

Map of how to get from Mainz to Prague.
Launch map view
  • Distance: 438.7 km
  • Duration: 3h 54m

What companies run services between Mainz, Germany and Prague, Czech Republic?

RegioJet operates a bus from Frankfurt Main Train Station to Prague Wilsonova Bus Station once daily. Tickets cost 360 Kč - 500 Kč and the journey takes 6h 15m. Alternatively, you can take a train from Mainz to Prague via Frankfurt(Main)Hbf, Nürnberg Hbf, and Schwandorf in around 9h 35m.

Airlines
Lufthansa
Website
lufthansa.com
Flights from Frankfurt to Prague
Ave. Duration
1h
When
Every day
Estimated price
2 800 Kč - 9 000 Kč
Flights from Frankfurt to Prague via Munich
Ave. Duration
2h 50m
When
Every day
Estimated price
2 800 Kč - 9 000 Kč
Flights from Frankfurt to Dresden
Ave. Duration
1h
When
Every day
Estimated price
1 900 Kč - 4 600 Kč
Flights from Frankfurt to Dresden via Munich
Ave. Duration
2h 50m
When
Monday, Tuesday, Wednesday, Thursday, Saturday and Sunday
Estimated price
1 800 Kč - 4 600 Kč
Air Dolomiti
Website
airdolomiti.it
Flights from Frankfurt to Dresden
Ave. Duration
1h
When
Monday to Saturday
Estimated price
2 300 Kč - 4 600 Kč
Train operators
Deutsche Bahn Intercity-Express

German rail company Deutsche Bahn is known for its efficient and comfortable service. It offers many different types of rail transportation, including ICE or Intercity-Express for high-speed services between major cities and regions, IC (InterCity) for long-distance trains, RE (Regional Express) trains that connect regions and cities, and the S-Bahn rapid transit service. There are two main tickets on offer: the Flexpreis that has full flexibility, and the Sparpreis which is the cheaper, advanced fare (bookings usually open 6 months in advance for domestic tickets).

Contact Details
Phone
+49 0180 6 99 66 33
Website
bahn.com
Train from Frankfurt(Main)Hbf to Nürnberg Hbf
Ave. Duration
2h 29m
Frequency
Hourly
Estimated price
1 000 Kč - 1 500 Kč
Website
Deutsche Bahn
Deutsche Bahn Regional

Deutsche Bahn’s regional network is made up of IRE (Interregio-Express), RE (Regional-Express), RB (Regionalbahn) and S-Bahn trains. Ticket prices are fixed and there’s no seat reservations – just turn up, buy a ticket and jump on the next train. All regional trains depart regularly and connect to local and long-distance services.

Contact Details
Phone
+49 30 311682904
Website
bahn.com
Train from Nürnberg Hbf to Schwandorf
Ave. Duration
1h 5m
Frequency
Hourly
Estimated price
370 Kč - 550 Kč
Website
Deutsche Bahn Regional
Die Länderbahn
Phone
0 89 54 888 97 - 25
Email
info@laenderbahn.com
Website
laenderbahn.com
Train from Schwandorf to Praha Hlavni Nadrazi
Ave. Duration
3h 25m
Frequency
Every 4 hours
Website
Die Länderbahn
Swiss Railways (SBB/CFF/FFS)

The national railway company of Switzerland, Swiss Railways operates trains throughout the country and adjacent European nations including Germany, France, Italy and Austria. Tickets are sold in two classes - First and Second - with most long-distance trains offering a bistro car serving beverages and snacks. Individual tickets can be bought easily at stands, while a variety of travel passes are on offer to suit different travel needs.

Contact Details
Phone
+41 51 220 11 11
Website
sbb.ch
Train from Frankfurt(Main)Hbf to Praha Hlavni Nadrazi
Ave. Duration
8h 46m
Frequency
Once daily
Estimated price
4 700 Kč - 8 500 Kč
Website
Swiss Railways (SBB/CFF/FFS)
Bus operators
FlixBus

One of Europe’s leading bus companies, Flixbus serves 2000+ destinations in 29 countries, including Germany, France, Italy, Austria, the Netherlands and Croatia and into Scandinavia and eastern Europe, as well as some US cities. Coaches have toilets, free WiFi and power outlets, plus snacks and drinks for purchase on board. Flixbus is a good choice for the budget-conscious traveller; purchase tickets in advance for the cheapest fares (note: there is no option to reserve a seat in advance).

Rome2rio's guide to FlixBus
Contact Details
Phone
+49 30 300 137 300
Email
service@flixbus.com
Website
flixbus.de
Bus from Dresden Hauptbahnhof to Prague
Ave. Duration
1h 50m
Frequency
Hourly
Estimated price
230 Kč - 280 Kč
Website
flixbus.co.uk
Frequently asked questions
Is there Wi-Fi on FlixBus?
Yes - FlixBus offers free Wi-Fi
Are there power outlets on FlixBus?
Yes
Does FlixBus offer meals or snacks?
Yes - snacks and drinks may be purchased from the driver. Please note, this is not available on all services.
For more information, please visit this page
RegioJet
Phone
+420 542 42 42 42
Email
info@regiojet.cz
Website
regiojet.com
Bus from Dresden Bayrische Strasse to Prague Florenc Central Bus Station
Ave. Duration
1h 55m
Frequency
5 times a day
Estimated price
120 Kč - 180 Kč
Website
RegioJet
Bus from Frankfurt Main Train Station to Prague Wilsonova Bus Station
Ave. Duration
6h 15m
Frequency
Once daily
Estimated price
360 Kč - 500 Kč
Website
RegioJet
Racic Eurobus
Phone
+359-887-208-506
Email
racic_bg@yahoo.com
Website
racicbg.com
Bus from Dresden Bayrische Strasse to Prague Florenc Central Bus Station
Ave. Duration
2h
Frequency
6 times a week
Website
Racic Eurobus
Comati PSG
Phone
0040 723 450 475
Email
info@comati-psg.ro
Website
comati-psg.ro
Bus from Dresden Bayrische Strasse to Prague Florenc Central Bus Station
Ave. Duration
2h 30m
Frequency
Twice a week
Estimated price
1 800 Kč - 2 200 Kč
Website
Comati PSG
Union Ivkoni
Phone
02/989 0000
Website
union-ivkoni.com
Bus from Dresden to Prague Florenc Central Bus Station
Ave. Duration
2h 30m
Frequency
Twice a week
Estimated price
110 Kč - 160 Kč
Website
Union Ivkoni
Pejic Tours
Phone
+381 20 314 545
Email
info@pejictours.com
Website
pejictours.com
Bus from Dresden to Prague
Ave. Duration
3h
Frequency
Twice a week
Schedules at
pejictours.com
Citylines
Phone
+359 2 812 0810
Email
support@citylines.bg
Website
citylines.eu
Bus from Dresden to Prague Florenc
Ave. Duration
3h
Frequency
Once a week
Website
Citylines

Want to know more about travelling around Czechia

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Frankfurt Airport to Prague Airport is the direct flight which takes 1h.

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Mainz to Prague bus services, operated by RegioJet, arrive at Prague Wilsonova Bus Station.

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Mainz to Prague train services, operated by Die Länderbahn, arrive at Praha Hlavni Nadrazi station.

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Yes, the driving distance between Mainz to Prague is 542 km. It takes approximately 4h 37m to drive from Mainz to Prague.

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Lufthansa offers flights from Frankfurt Airport to Prague Airport.

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Book your Mainz to Prague bus tickets online with Omio and Distribusion.

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There are 697+ hotels available in Prague. Prices start at 2 000 Kč per night.

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The best way to get from Mainz to Frankfurt Airport is to train which takes 23 min and costs €5 - €8.

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