There are 8 ways to get from Mainz to Prague by plane, subway, train, bus, night train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Václav Havel Airport Prague, subway
best- Fly from Frankfurt (FRA) to Václav Havel Airport Prague (PRG)FRA - PRG
- Take the subway from Nádraží Veleslavín to Staroměstská
3h 55mBus
cheapest- Take the bus from Mainz central train station to PragueN1310
8h 5mKč 700–1,400Train, bus
- Take the train from Mainz, Hauptbahnhof to Dresden Hauptbahnhof50
- Take the bus from Dresden central station to Praha, ÚAN Florenc060 / ...
7h 15mKč 1,724–3,805Night train
- Take the night train from Mainz Hbf to Praha Hlavni NadraziEn
9hKč 3,200–4,500Fly to Dresden Airport, bus
- Fly from Frankfurt (FRA) to Dresden Airport (DRS)FRA - DRS
- Take the bus from Dresden central station to Praha, ÚAN Florenc
5h 20mKč 3,590–7,942Train
- Take the train from Mainz, Hauptbahnhof to Dresden Bahnhof Neustadt50
- Take the train from Dresden-Neustadt to Praha Hlavni NadraziRj
8h 19mKč 2,796–3,493Bus via Frankfurt am Main
- Take the bus from Frankfurt am Main to Prague Florenc Bus Station
10h 28mDrive 508.2 km
- Drive from Mainz to Prague508.2 km
5h 28mKč 1,859–2,684
Mainz to Prague by train and bus
Questions & Answers
The cheapest way to get from Mainz to Prague is to bus which costs 700 Kč - 1 400 Kč and takes 8h 5m.
The fastest way to get from Mainz to Prague is to fly and bus which takes 5h 20m and costs 3 500 Kč - 8 000 Kč.
Yes, there is a direct bus departing from Mainz central train station station and arriving at Prague. Services depart once daily, and operate every day. The journey takes approximately 8h 5m.
Yes, there is an overnight train departing from Mainz Hbf and arriving at Praha Hlavni Nadrazi. This train operates Thursday. The journey takes approximately 9h.
The distance between Mainz and Prague is 448 km. The road distance is 508.2 km.
The best way to get from Mainz to Prague without a car is to train and bus which takes 7h 15m and costs 1 700 Kč - 3 900 Kč.
It takes approximately 3h 55m to get from Mainz to Prague, including transfers.
Mainz to Prague bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Prague train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
The best way to get from Mainz to Prague is to bus which takes 8h 5m and costs 700 Kč - 1 400 Kč. Alternatively, you can train, which costs 2 800 Kč - 3 500 Kč and takes 8h 19m.
What companies run services between Mainz, Germany and Prague, Czechia?
FlixBus operates a bus from Mainz central train station to Prague once daily. Tickets cost Kč 700–1,400 and the journey takes 8h 5m. Alternatively, ÖBB operates a vehicle from Mainz Hbf to Praha Hlavni Nadrazi once a week. Tickets cost Kč 3,200–4,500 and the journey takes 9h.
- Website
- lufthansa.com
Flights from Frankfurt to Václav Havel Airport Prague
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- Kč 1,900–7,500
Flights from Frankfurt to Václav Havel Airport Prague via Munich
- Ave. Duration
- 2h 50m
- When
- Every day
- Estimated price
- Kč 1,900–4,100
Flights from Frankfurt to Dresden Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- Kč 3,000–7,000
Flights from Frankfurt to Dresden Airport via Munich
- Ave. Duration
- 2h 47m
- When
- Every day
- Estimated price
- Kč 3,000–7,000
- Website
- condor.com
Flights from Frankfurt to Václav Havel Airport Prague
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- Kč 1,500–3,100
- Website
- airdolomiti.it
Flights from Frankfurt to Václav Havel Airport Prague
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- Kč 2,100–7,500
- Phone
- +420 234 704 560
- info@pid.cz
- Website
- pid.cz
Subway from Nádraží Veleslavín to Staroměstská
- Ave. Duration
- 8 min
- Frequency
- Every 10 minutes
- Website
- https://pid.cz/en/
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mainz, Hauptbahnhof to Dresden Hauptbahnhof
- Ave. Duration
- 5h 3m
- Frequency
- Every 3 hours
- Estimated price
- Kč 1,500–3,000
- Website
- https://int.bahn.de/en
Train from Mainz, Hauptbahnhof to Dresden Bahnhof Neustadt
- Ave. Duration
- 4h 56m
- Frequency
- Every 3 hours
- Estimated price
- Kč 2,000–2,200
- Website
- https://int.bahn.de/en
#/media/File:ICE_4_Berlin_Hauptbahnhof_(3).jpg "ICE 4 Berlin Hauptbahnhof")
Night train from Mainz Hbf to Praha Hlavni Nadrazi
- Ave. Duration
- 9h
- Frequency
- Once a week
- Estimated price
- Kč 3,200–4,500
- Website
- https://www.oebb.at/en/
- Phone
- +47 70 13 14 15
- kundehenv@dsb.dk
- Website
- dsb.dk
Train from Dresden-Neustadt to Praha Hlavni Nadrazi
- Ave. Duration
- 2h 23m
- Frequency
- Twice daily
- Estimated price
- Kč 800–1,300
- Website
- https://www.dsb.dk/en/
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Dresden central station to Praha, ÚAN Florenc
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- Kč 330–900
- Website
- https://www.flixbus.co.uk
Bus from Mainz central train station to Prague
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- Kč 700–1,400
- Website
- https://www.flixbus.co.uk
- Phone
- +420 222 222 221
- info@regiojet.cz
- Website
- regiojet.com
Bus from Dresden central station to Praha, ÚAN Florenc
- Ave. Duration
- 1h 55m
- Frequency
- Every 4 hours
- Estimated price
- Kč 200–300
- Website
- https://regiojet.com/
- Phone
- +359-887-208-506
- racic_bg@yahoo.com
- Website
- racicbg.com
Bus from Dresden central station to Praha, ÚAN Florenc
- Ave. Duration
- 2h
- Frequency
- 3 times a week
- Estimated price
- Kč 600–800
- Website
- https://www.racicbg.com/bg/
- Phone
- 07001 8282
- booking@union-ivkoni.com
- Website
- union-ivkoni.com
Bus from Dresden central station to Praha, ÚAN Florenc
- Ave. Duration
- 2h
- Frequency
- Twice a week
- Estimated price
- Kč 150–220
- Website
- https://union-ivkoni.com/en
- helpline.svs@gmail.com
- Website
- svs.md
Bus from Frankfurt am Main to Prague Florenc Bus Station
- Ave. Duration
- 8h 43m
- Frequency
- Once a week
- Website
- https://svs.md/en/bus/route/number-19167
Want to know more about travelling around Czechia
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
More Questions & Answers
Mainz to Prague bus services, operated by FlixBus, arrive at Prague station.
Mainz to Prague train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Dresden Bahnhof Neustadt station.
Yes, the driving distance between Mainz to Prague is 508 km. It takes approximately 5h 28m to drive from Mainz to Prague.
Book your Mainz to Prague train tickets online with Omio.
Book your Mainz to Prague bus tickets online with Omio and FlixBus.
There are 4060+ hotels available in Prague.