There are 7 ways to get from Mainz to Prague by plane, subway, bus, train, night train or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.
Recommended option
Fly to Prague, subway • 3h 54m
Cheapest option
Bus • 7h 55m
5 alternative options
Fly to Dresden, bus • 5h 12m
Train via Nuremberg • 9h 35m
Train • 10h 24m
Night train • 10h 19m
Drive • 4h 37m
Questions & Answers
The cheapest way to get from Mainz to Prague is to bus which costs €20 - €28 and takes 7h 55m.
The fastest way to get from Mainz to Prague is to fly and subway which takes 3h 54m and costs €85 - €310.
No, there is no direct bus from Mainz station to Prague station. However, there are services departing from Mainz central train station and arriving at Prague Wilsonova Bus Station via Frankfurt Main Train Station. The journey, including transfers, takes approximately 7h 55m.
No, there is no direct train from Mainz to Prague. However, there are services departing from Mainz, Römisches Theater and arriving at Praha Hlavni Nadrazi via Frankfurt(Main)Hbf, Nürnberg Hbf and Schwandorf. The journey, including transfers, takes approximately 9h 35m.
The distance between Mainz and Prague is 439 km. The road distance is 542 km.
The best way to get from Mainz to Prague without a car is to bus which takes 7h 55m and costs €20 - €28.
It takes approximately 3h 54m to get from Mainz to Prague, including transfers.
Mainz to Prague bus services, operated by RegioJet, depart from Frankfurt Main Train Station.
Mainz to Prague train services, operated by Deutsche Bahn Intercity-Express, depart from Frankfurt(Main)Hbf station.
The best way to get from Mainz to Prague is to bus which takes 7h 55m and costs €20 - €28. Alternatively, you can train via Nuremberg, which costs and takes 9h 35m.

- Distance: 438.7 km
- Duration: 3h 54m
What companies run services between Mainz, Germany and Prague, Czech Republic?
RegioJet operates a bus from Frankfurt Main Train Station to Prague Wilsonova Bus Station once daily. Tickets cost 360 Kč - 500 Kč and the journey takes 6h 15m. Alternatively, you can take a train from Mainz to Prague via Frankfurt(Main)Hbf, Nürnberg Hbf, and Schwandorf in around 9h 35m.

- Website
- lufthansa.com
Flights from Frankfurt to Prague
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- 2 800 Kč - 9 000 Kč
Flights from Frankfurt to Prague via Munich
- Ave. Duration
- 2h 50m
- When
- Every day
- Estimated price
- 2 800 Kč - 9 000 Kč
Flights from Frankfurt to Dresden
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- 1 900 Kč - 4 600 Kč
Flights from Frankfurt to Dresden via Munich
- Ave. Duration
- 2h 50m
- When
- Monday, Tuesday, Wednesday, Thursday, Saturday and Sunday
- Estimated price
- 1 800 Kč - 4 600 Kč

- Website
- airdolomiti.it
Flights from Frankfurt to Dresden
- Ave. Duration
- 1h
- When
- Monday to Saturday
- Estimated price
- 2 300 Kč - 4 600 Kč

- Phone
- 296 19 18 17
- Website
- dpp.cz
Subway from Nádraží Veleslavín to Staroměstská
- Ave. Duration
- 8 min
- Frequency
- Every 10 minutes
- Estimated price
- 24 Kč - 35 Kč
- Website
- Dopravní podnik hl. m. Prahy, akciová společnost

German rail company Deutsche Bahn is known for its efficient and comfortable service. It offers many different types of rail transportation, including ICE or Intercity-Express for high-speed services between major cities and regions, IC (InterCity) for long-distance trains, RE (Regional Express) trains that connect regions and cities, and the S-Bahn rapid transit service. There are two main tickets on offer: the Flexpreis that has full flexibility, and the Sparpreis which is the cheaper, advanced fare (bookings usually open 6 months in advance for domestic tickets).
Contact Details
- Phone
- +49 0180 6 99 66 33
- Website
- bahn.com
Train from Frankfurt(Main)Hbf to Nürnberg Hbf
- Ave. Duration
- 2h 29m
- Frequency
- Hourly
- Estimated price
- 1 000 Kč - 1 500 Kč
- Website
- Deutsche Bahn

Deutsche Bahn’s regional network is made up of IRE (Interregio-Express), RE (Regional-Express), RB (Regionalbahn) and S-Bahn trains. Ticket prices are fixed and there’s no seat reservations – just turn up, buy a ticket and jump on the next train. All regional trains depart regularly and connect to local and long-distance services.
Contact Details
- Phone
- +49 30 311682904
- Website
- bahn.com
Train from Nürnberg Hbf to Schwandorf
- Ave. Duration
- 1h 5m
- Frequency
- Hourly
- Estimated price
- 370 Kč - 550 Kč
- Website
- Deutsche Bahn Regional

- Phone
- 0 89 54 888 97 - 25
- info@laenderbahn.com
- Website
- laenderbahn.com
Train from Schwandorf to Praha Hlavni Nadrazi
- Ave. Duration
- 3h 25m
- Frequency
- Every 4 hours
- Website
- Die Länderbahn

The national railway company of Switzerland, Swiss Railways operates trains throughout the country and adjacent European nations including Germany, France, Italy and Austria. Tickets are sold in two classes - First and Second - with most long-distance trains offering a bistro car serving beverages and snacks. Individual tickets can be bought easily at stands, while a variety of travel passes are on offer to suit different travel needs.
Contact Details
- Phone
- +41 51 220 11 11
- Website
- sbb.ch
Train from Frankfurt(Main)Hbf to Praha Hlavni Nadrazi
- Ave. Duration
- 8h 46m
- Frequency
- Once daily
- Estimated price
- 4 700 Kč - 8 500 Kč
- Website
- Swiss Railways (SBB/CFF/FFS)

- Website
- bahn.com
Night train from Frankfurt(Main)Hbf to Praha Hlavni Nadrazi
- Ave. Duration
- 8h 41m
- Frequency
- Once daily
- Estimated price
- 1 400 Kč - 2 000 Kč
- Website
- reiseauskunft.bahn.de

One of Europe’s leading bus companies, Flixbus serves 2000+ destinations in 29 countries, including Germany, France, Italy, Austria, the Netherlands and Croatia and into Scandinavia and eastern Europe, as well as some US cities. Coaches have toilets, free WiFi and power outlets, plus snacks and drinks for purchase on board. Flixbus is a good choice for the budget-conscious traveller; purchase tickets in advance for the cheapest fares (note: there is no option to reserve a seat in advance).
Rome2rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.de
Bus from Dresden Hauptbahnhof to Prague
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- 230 Kč - 280 Kč
- Website
- flixbus.co.uk
Frequently asked questions

- Phone
- +420 542 42 42 42
- info@regiojet.cz
- Website
- regiojet.com
Bus from Dresden Bayrische Strasse to Prague Florenc Central Bus Station
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a day
- Estimated price
- 120 Kč - 180 Kč
- Website
- RegioJet
Bus from Frankfurt Main Train Station to Prague Wilsonova Bus Station
- Ave. Duration
- 6h 15m
- Frequency
- Once daily
- Estimated price
- 360 Kč - 500 Kč
- Website
- RegioJet

- Phone
- +359-887-208-506
- racic_bg@yahoo.com
- Website
- racicbg.com
Bus from Dresden Bayrische Strasse to Prague Florenc Central Bus Station
- Ave. Duration
- 2h
- Frequency
- 6 times a week
- Website
- Racic Eurobus

- Phone
- 0700 20 544
- Website
- ardatur.bg
Bus from Dresden Central Train Station to Prague Florenc Central Bus Station
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- 280 Kč - 340 Kč
- Website
- Arda Tur

- Phone
- 0040 723 450 475
- info@comati-psg.ro
- Website
- comati-psg.ro
Bus from Dresden Bayrische Strasse to Prague Florenc Central Bus Station
- Ave. Duration
- 2h 30m
- Frequency
- Twice a week
- Estimated price
- 1 800 Kč - 2 200 Kč
- Website
- Comati PSG

- Phone
- 02/989 0000
- Website
- union-ivkoni.com
Bus from Dresden to Prague Florenc Central Bus Station
- Ave. Duration
- 2h 30m
- Frequency
- Twice a week
- Estimated price
- 110 Kč - 160 Kč
- Website
- Union Ivkoni

- Phone
- +381 20 314 545
- info@pejictours.com
- Website
- pejictours.com
Bus from Dresden to Prague
- Ave. Duration
- 3h
- Frequency
- Twice a week
- Schedules at
- pejictours.com

- Phone
- +359 2 812 0810
- support@citylines.bg
- Website
- citylines.eu
Bus from Dresden to Prague Florenc
- Ave. Duration
- 3h
- Frequency
- Once a week
- Website
- Citylines
Want to know more about travelling around Czechia
Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
More Questions & Answers
The quickest flight from Frankfurt Airport to Prague Airport is the direct flight which takes 1h.
Mainz to Prague bus services, operated by RegioJet, arrive at Prague Wilsonova Bus Station.
Mainz to Prague train services, operated by Die Länderbahn, arrive at Praha Hlavni Nadrazi station.
Yes, the driving distance between Mainz to Prague is 542 km. It takes approximately 4h 37m to drive from Mainz to Prague.
Lufthansa offers flights from Frankfurt Airport to Prague Airport.
Book your Mainz to Prague bus tickets online with Omio and Distribusion.
There are 697+ hotels available in Prague. Prices start at 2 000 Kč per night.
The best way to get from Mainz to Frankfurt Airport is to train which takes 23 min and costs €5 - €8.