The average bus between Mainz and Karlsruhe takes 4h 20m and the fastest bus takes 3h 50m. The bus service runs several times per day from Mainz to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Mainz and Karlsruhe. The earliest departure is at 5:10 AM in the morning, and the last departure from Mainz is at 8:00 PM which arrives into Karlsruhe at 10:50 PM. All services require a transfer, and take on average 4h 20m. The schedules shown below are for the next available departures.
Want to know about travelling from Mainz to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mainz to Karlsruhe. However, there are services departing from Mainz station and arriving at Karlsruhe station via Frankfurt Airport. The journey, including transfers, takes approximately 4h 20m.
Mainz to Karlsruhe bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Karlsruhe bus services, operated by FlixBus, arrive at Karlsruhe - Central Station South Side.
Book your Mainz to Karlsruhe bus tickets online with FlixBus.
The distance between Mainz and Karlsruhe is 108.8 km. The road distance is 166 km.
You can take a bus from Mainz central train station to Karlsruhe - Central Station South Side via Frankfurt - Airport Bus Station in around 2h 40m.
