The average train between Mainz and Brussels takes 4h 12m and the fastest train takes 4h 3m. The train service runs several times per day from Mainz to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Brussels. The earliest departure is at 5:05 AM in the morning, and the last departure from Mainz is at 7:14 PM which arrives into Brussels at 11:26 PM. All services require a transfer, and take on average 4h 12m. The schedules shown below are for the next available departures.

4h 21m • 1 change

4h 21m • 1 change

4h 12m • 1 change

4h 12m • 1 change

4h 21m • 1 change

4h 21m • 1 change

4h 12m • 1 change

4h 12m • 1 change

4h 17m • 1 change

4h 13m • 1 change

4h 12m • 1 change

4h 12m • 1 change

4h 17m • 1 change

4h 13m • 1 change

4h 12m • 1 change

4h 12m • 1 change

4h 17m • 1 change

4h 13m • 1 change

4h 12m • 1 change

4h 12m • 1 change

4h 17m • 1 change

4h 13m • 1 change

4h 12m • 1 change

4h 12m • 1 change
Want to know about travelling from Mainz to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Brussels. However, there are services departing from Mainz station and arriving at Brussels station via Brussels-Nord. The journey, including transfers, takes approximately 4h 12m.
Mainz to Brussels train services, operated by vlexx, depart from Frankfurt station.
Mainz to Brussels train services, operated by vlexx, arrive at Brussels-Nord station.
Book your Mainz to Brussels train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz and Brussels is 294.6 km. The road distance is 411 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Brussels-Nord every 4 hours. Tickets cost €70–210 and the journey takes 3h 27m. Belgian Railways (NMBS/SNCB) also services this route once a week.