The average train between Mainz and Brussels takes 3h 26m and the fastest train takes 3h 12m. The train service runs several times per day from Mainz to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Mainz and Brussels. The earliest departure is at 5:05 AM in the morning, and the last departure from Mainz is at 7:35 PM which arrives into Brussels at 11:26 PM. All services require a transfer, and take on average 3h 26m. The schedules shown below are for the next available departures.

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 51m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

3h 12m • 1 change

4h 21m • 1 change

4h 21m • 1 change

4h 12m • 1 change

4h 12m • 1 change
Want to know about travelling from Mainz to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Brussels. However, there are services departing from Mainz station and arriving at Brussels station via Brussels-Nord. The journey, including transfers, takes approximately 3h 26m.
Mainz to Brussels train services, operated by Süwex, depart from Frankfurt station.
Mainz to Brussels train services, operated by Süwex, arrive at Brussels-Nord station.
Book your Mainz to Brussels train tickets online with Süwex, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz and Brussels is 294.6 km. The road distance is 411 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Brussels-Nord every 4 hours. Tickets cost €70–190 and the journey takes 3h 27m. Belgian Railways (NMBS/SNCB) also services this route twice a week.