The average train between Mainz and Brussels takes 4h 34m and the fastest train takes 4h 15m. The train service runs several times per day from Mainz to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Mainz and Brussels. The earliest departure is at 3:49 AM at night, and the last departure from Mainz is at 7:20 PM which arrives into Brussels at 11:35 PM. All services require a transfer, and take on average 4h 34m. The schedules shown below are for the next available departures.

4h 46m • 1 change

4h 18m • 1 change

4h 15m • 1 change

4h 15m • 1 change
Want to know about travelling from Mainz to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Brussels. However, there are services departing from Mainz station and arriving at Brussels station via Köln Hbf. The journey, including transfers, takes approximately 4h 34m.
Mainz to Brussels train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Brussels train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Bruxelles Midi station.
Book your Mainz to Brussels train tickets online with Deutsche Bahn Intercity (DB IC), Nederlandse Spoorwegen (NS) and 2 other operators.
The distance between Mainz and Brussels is 294.6 km. The road distance is 401 km.
You can take a train from Mainz, Hauptbahnhof to Bruxelles Midi via Köln Hbf in around 4h 28m.