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Madrid to Mendrisio trains

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Trip Overview

The train between Madrid and Mendrisio takes 27h 12m. The train runs, on average, 5 times per week from Madrid to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

27h 12m
Duration
1,766 km
Distance
CHF 242
Average price
5 times a week
Frequency

Madrid to Mendrisio train times

Trains run 5 times a week between Madrid and Mendrisio. The service departs Madrid at 8:30 PM in the evening, which arrives into Mendrisio at 23:42:00. All services require a transfer at Barcelona-Sants and take an average of 27h 12m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

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    Arrives next day

    Renfe AVERenfe ViajerosTrenitaliaSwiss Federal Railways (SBB CFF FFS)27h 12m • 3 changes

Departing Monday, November 9, 2026

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    Arrives next day

    Renfe AVERenfe ViajerosTrenitaliaSwiss Federal Railways (SBB CFF FFS)27h 12m • 3 changes

Departing Tuesday, November 10, 2026

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    Arrives next day

    Renfe AVERenfe ViajerosTrenitaliaSwiss Federal Railways (SBB CFF FFS)27h 12m • 3 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Renfe AVERenfe ViajerosTrenitaliaSwiss Federal Railways (SBB CFF FFS)27h 12m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Renfe AVERenfe ViajerosTrenitaliaSwiss Federal Railways (SBB CFF FFS)27h 12m • 3 changes

Frequently asked questions

Want to know about travelling from Madrid to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Madrid to Mendrisio.ExpandLaunch map view
  • Distance: 1,765.8 km
  • Duration: 27h 12m

What companies run services between Madrid, Spain and Mendrisio, Switzerland?

You can take a train from Madrid-Puerta de Atocha-Almudena Grandes to Mendrisio via Barcelona-Sants, Lyon Part Dieu, and Milano Centrale in around 16h 26m.

Operators