The train between Venice and Mendrisio takes 3h 44m. The train service runs several times per day from Venice to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Venice and Mendrisio. The earliest departure is at 5:57 AM in the morning, and the last departure from Venice is at 5:57 PM which arrives into Mendrisio at 9:41 PM. All services require a transfer, and take on average 3h 44m. The schedules shown below are for the next available departures.

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Want to know about travelling from Venice to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Venice to Mendrisio. However, there are services departing from Venice station and arriving at Mendrisio station via Milano Centrale. The journey, including transfers, takes approximately 3h 44m.
Venice to Mendrisio train services, operated by ItaloTreno, depart from Venezia Santa Lucia station.
Venice to Mendrisio train services, operated by ItaloTreno, arrive at Mendrisio station.
The distance between Venice and Mendrisio is 264.4 km. The road distance is 324 km.
You can take a train from Venezia Santa Lucia to Mendrisio via Milano Centrale in around 4h 2m.