The average train between Lyon and Prague takes 24h 26m and the fastest train takes 21h 49m. There is at least one train per day from Lyon to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Lyon and Prague. The earliest departure is at 11:38 AM in the morning, and the last departure from Lyon is at 6:00 PM which arrives into Prague at 8:21 PM. All services require a transfer at Strasbourg and take an average of 24h 26m. The schedules shown below are for the next available departures.
Arrives next day



21h 49m • 3 changes
Arrives next day



26h 21m • 3 changes
Arrives next day



22h 43m • 3 changes
Arrives next day



26h 21m • 3 changes
Arrives next day



22h 43m • 3 changes
Arrives next day



26h 21m • 3 changes
Want to know about travelling from Lyon to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Lyon to Prague. However, there are services departing from Lyon station and arriving at Prague station via Strasbourg. The journey, including transfers, takes approximately 24h 26m.
Lyon to Prague train services, operated by TGV inOui, depart from Lyon Part Dieu station.
Lyon to Prague train services, operated by TGV inOui, arrive at Praha Hlavni Nadrazi station.
Book your Lyon to Prague train tickets online with TGV inOui, Deutsche Bahn Intercity (DB IC) and Die Länderbahn.
The distance between Lyon and Prague is 860.3 km. The road distance is 1,324 km.
You can take a train from Lyon Part Dieu to Praha Hlavni Nadrazi via Strasbourg, Stuttgart Hbf, Hauptbahnhof, and Muenchen Hbf in around 15h 16m.