The average train between Potsdam and Prague takes 4h 31m and the fastest train takes 4h 25m. The train service runs several times per day from Potsdam to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Potsdam and Prague. The earliest departure is at 6:32 AM in the morning, and the last departure from Potsdam is at 4:49 PM which arrives into Prague at 9:15 PM. All services require a transfer at Berlin Hbf and take an average of 4h 31m. The schedules shown below are for the next available departures.

4h 25m • 1 change

4h 26m • 1 change

4h 43m • 1 change

4h 26m • 1 change

4h 25m • 1 change

4h 26m • 1 change

4h 43m • 1 change

4h 26m • 1 change
Want to know about travelling from Potsdam to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Potsdam to Prague. However, there are services departing from Potsdam station and arriving at Prague station via Praha-Holesovice. The journey, including transfers, takes approximately 4h 31m.
Potsdam to Prague train services, operated by ODEG, depart from Berlin Hbf(Tief) station.
Potsdam to Prague train services, operated by ODEG, arrive at Praha-Holesovice station.
Book your Potsdam to Prague train tickets online with ODEG, Railjet and Danish Railways (DSB).
The distance between Potsdam and Prague is 273.7 km. The road distance is 394 km.
Danish Railways (DSB) operates a train from Berlin Hbf(Tief) to Praha-Holesovice twice daily. Tickets cost Kč 1,800–2,800 and the journey takes 3h 47m. Railjet also services this route twice daily.