The average train between Prague and Leipzig takes 3h 57m and the fastest train takes 3h 50m. The train service runs several times per day from Prague to Leipzig. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Prague and Leipzig. The earliest departure is at 6:41 AM in the morning, and the last departure from Prague is at 6:41 PM which arrives into Leipzig at 10:50 PM. All services require a transfer, and take on average 3h 57m. The schedules shown below are for the next available departures.

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Want to know about travelling from Prague to Leipzig? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prague to Leipzig. However, there are services departing from Prague station and arriving at Leipzig station via Dresden-Neustadt. The journey, including transfers, takes approximately 3h 57m.
Prague to Leipzig train services, operated by ÖBB EuroCity, depart from Praha-Holesovice station.
Prague to Leipzig train services, operated by ÖBB EuroCity, arrive at Leipzig Hbf station.
Book your Prague to Leipzig train tickets online with ÖBB EuroCity, Deutsche Bahn Regio (DB Regional) and 4 other operators.
The distance between Prague and Leipzig is 200.5 km. The road distance is 303 km.
You can take a train from Praha-Holesovice to Leipzig Hbf via Dresden Bahnhof Neustadt in around 3h 35m.