The average train between Istres and Lyon takes 6h 16m and the fastest train takes 3h 21m. The train service runs several times per day from Istres to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Istres and Lyon. The earliest departure is at 8:16 AM in the morning, and the last departure from Istres is at 9:49 PM which arrives into Lyon at 10:50 AM. All services require a transfer at Miramas and take an average of 6h 16m. The schedules shown below are for the next available departures.


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3h 21m • 2 changes
Want to know about travelling from Istres to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Istres to Lyon. However, there are services departing from Istres station and arriving at Lyon station via Nimes Pont Du Gard. The journey, including transfers, takes approximately 6h 16m.
Istres to Lyon train services, operated by Zou! Lignes Express Régionales, depart from Miramas station.
Istres to Lyon train services, operated by Zou! Lignes Express Régionales, arrive at Lyon Part Dieu station.
Book your Istres to Lyon train tickets online with Zou! Lignes Express Régionales, TGV inOui and Société Nationale des Chemins de fer Français (SNCF).
The distance between Istres and Lyon is 248.8 km. The road distance is 323 km.
You can take a train from Istres to Lyon Part Dieu via Miramas and Nimes Pont Du Gard in around 3h 58m.