The average bus between Istres and Lyon takes 6h 40m and the fastest bus takes 5h 33m. The bus service runs several times per day from Istres to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Istres and Lyon. The earliest departure is at 6:37 AM in the morning, and the last departure from Istres is at 7:04 PM which arrives into Lyon at 2:55 AM. All services require a transfer at Gare Routière and take an average of 6h 40m. The schedules shown below are for the next available departures.


6h 38m • 2 changes


6h 23m • 2 changes


6h 4m • 2 changes
Arrives next day


5h 33m • 2 changes


8h 4m • 2 changes


7h 34m • 2 changes
Arrives next day


6h 13m • 2 changes


7h 47m • 2 changes


6h 1m • 2 changes
Arrives next day


6h 21m • 2 changes
Arrives next day


7h 51m • 2 changes
Want to know about travelling from Istres to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Istres to Lyon. However, there are services departing from Istres station and arriving at Lyon station via Lyon - Gerland Bus Station station. The journey, including transfers, takes approximately 6h 40m.
Istres to Lyon bus services, operated by Ouest Étang, depart from Aix-en-Provence - Krypton Park & Ride station.
Istres to Lyon bus services, operated by Ouest Étang, arrive at Lyon - Gerland Bus Station.
The distance between Istres and Lyon is 248.8 km. The road distance is 363 km.
BlaBlaCar Bus operates a bus from Aix-en-Provence - Krypton Park & Ride to Lyon - Gerland Bus Station every 3 hours. Tickets cost €22–40 and the journey takes 3h 35m. FlixBus also services this route 4 times a day.