The average bus between Istres and Lyon takes 7h 10m and the fastest bus takes 5h 22m. The bus service runs several times per day from Istres to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Istres and Lyon. The earliest departure is at 7:04 AM in the morning, and the last departure from Istres is at 8:14 PM which arrives into Lyon at 10:50 AM. All services require a transfer at La Rode and take an average of 7h 10m. The schedules shown below are for the next available departures.


3h 22m • 2 changes


7h 8m • 2 changes


6h 6m • 2 changes


6h 52m • 2 changes


7h 9m • 2 changes


6h 25m • 2 changes


7h 14m • 2 changes
Arrives next day


7h 5m • 2 changes


3h 46m • 2 changes


6h 57m • 2 changes


6h 29m • 2 changes


6h 41m • 2 changes


3h 46m • 2 changes


6h 57m • 2 changes


6h 29m • 2 changes


6h 41m • 2 changes


3h 46m • 2 changes


6h 57m • 2 changes


6h 41m • 2 changes
Arrives next day


5h 38m • 2 changes
Want to know about travelling from Istres to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Istres to Lyon. However, there are services departing from Istres station and arriving at Lyon station via Lyon - Gerland Bus Station station. The journey, including transfers, takes approximately 7h 10m.
Istres to Lyon bus services, operated by Ouest Étang, depart from Marseille - Saint-Charles Bus Station.
Istres to Lyon bus services, operated by Ouest Étang, arrive at Lyon - Gerland Bus Station.
The distance between Istres and Lyon is 248.8 km. The road distance is 363 km.
BlaBlaCar Bus operates a bus from Marseille - Saint-Charles Bus Station to Lyon - Gerland Bus Station hourly. Tickets cost €22–45 and the journey takes 3h 40m. FlixBus also services this route twice daily.