The average train between Isernia and Tuscany takes 5h 45m and the fastest train takes 3h 52m. The train service runs several times per day from Isernia to Tuscany. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Isernia and Tuscany. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Tuscany at 6:46 AM. All services require a transfer, and take on average 5h 45m. The schedules shown below are for the next available departures.

7h 8m • 1 change

6h 43m • 1 change
Arrives next day

11h 11m • 1 change

4h 6m • 1 change

4h 33m • 1 change

4h 8m • 1 change

4h 58m • 1 change

4h 6m • 1 change

4h 33m • 1 change

4h 8m • 1 change

5h 20m • 1 change

4h 6m • 1 change

4h 33m • 1 change

3h 52m • 1 change

4h • 1 change

4h 6m • 1 change

4h 33m • 1 change

4h 8m • 1 change

4h 58m • 1 change

4h 6m • 1 change

4h 33m • 1 change

4h 8m • 1 change

4h 58m • 1 change
Want to know about travelling from Isernia to Tuscany? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Tuscany. However, there are services departing from Isernia station and arriving at Tuscany station via Roma Termini. The journey, including transfers, takes approximately 5h 45m.
Isernia to Tuscany train services, operated by Trenitalia, depart from Isernia station.
Isernia to Tuscany train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
Book your Isernia to Tuscany train tickets online with Trenitalia and Trenitalia Frecce.
The distance between Isernia and Tuscany is 327.4 km. The road distance is 447 km.
You can take a train from Isernia to Firenze S.M.N. via Roma Termini in around 4h 1m.