The average train between Isernia and Tuscany takes 5h 36m and the fastest train takes 3h 50m. The train service runs several times per day from Isernia to Tuscany. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Isernia and Tuscany. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Tuscany at 7:17 AM. All services require a transfer, and take on average 5h 36m. The schedules shown below are for the next available departures.

4h 37m • 1 change

3h 53m • 1 change

3h 58m • 1 change

3h 50m • 1 change

4h 37m • 1 change

3h 53m • 1 change

4h 14m • 1 change
Arrives next day

10h 42m • 1 change

4h 37m • 1 change

3h 53m • 1 change

4h 14m • 1 change
Arrives next day

10h 42m • 1 change

4h 37m • 1 change

3h 53m • 1 change

4h 14m • 1 change
Arrives next day

10h 42m • 1 change
Want to know about travelling from Isernia to Tuscany? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Tuscany. However, there are services departing from Isernia station and arriving at Tuscany station via Roma Termini. The journey, including transfers, takes approximately 5h 36m.
Isernia to Tuscany train services, operated by Trenitalia, depart from Isernia station.
Isernia to Tuscany train services, operated by Trenitalia, arrive at Firenze Santa Maria Novella station.
Book your Isernia to Tuscany train tickets online with Trenitalia and ItaloTreno.
The distance between Isernia and Tuscany is 327.4 km. The road distance is 447 km.
You can take a train from Isernia to Firenze Santa Maria Novella via Roma Termini in around 4h 13m.