The train between Asti and Mendrisio takes 2h 47m. The train service runs several times per day from Asti to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Asti and Mendrisio. The earliest departure is at 8:54 AM in the morning, and the last departure from Asti is at 8:54 PM which arrives into Mendrisio at 11:42 PM. All services require a transfer, and take on average 2h 47m. The schedules shown below are for the next available departures.

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Want to know about travelling from Asti to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Asti to Mendrisio. However, there are services departing from Asti station and arriving at Mendrisio station via Milano Centrale. The journey, including transfers, takes approximately 2h 47m.
Asti to Mendrisio train services, operated by Trenord, depart from Asti station.
Asti to Mendrisio train services, operated by Trenord, arrive at Mendrisio station.
The distance between Asti and Mendrisio is 123.8 km. The road distance is 195 km.
You can take a train from Asti to Mendrisio via Milano Centrale in around 3h 15m.